DOI: 10.1126/science.2961059. YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation

YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation

10.1126/science.2961059

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachment and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence of laminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro.

Bibliography

Iwamoto, Y., Robey, F. A., Graf, J., Sasaki, M., Kleinman, H. K., Yamada, Y., & Martin, G. R. (1987). YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation. Science, 238(4830), 1132â1134.

Authors 7

Yukihide Iwamoto (first)
Frank A. Robey (additional)
Jeannette Graf (additional)
Makoto Sasaki (additional)
Hynda K. Kleinman (additional)
Yoshihiko Yamada (additional)
George R. Martin (additional)

References 30 Referenced 428

AKIYAMA, S.K., THE INTERACTION OF PLASMA FIBRONECTIN WITH FIBROBLASTIC CELLS IN SUSPENSION, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 4492 (1985). (10.1016/S0021-9258(18)89291-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1985)
ALBINI, A, A RAPID INVITRO ASSAY FOR QUANTITATING THE INVASIVE POTENTIAL OF TUMOR-CELLS, CANCER RESEARCH 47: 3239 (1987). / CANCER RESEARCH (1987)
BARLOW, D.P., SEQUENCING OF LAMININ-B CHAIN CDNAS REVEALS C-TERMINAL REGIONS OF COILED-COIL ALPHA-HELIX, EMBO JOURNAL 3: 2355 (1984). (10.1002/j.1460-2075.1984.tb02140.x) / EMBO JOURNAL (1984)
BARSKY, S.H., CHARACTERIZATION OF A LAMININ RECEPTOR FROM HUMAN-BREAST CARCINOMA TISSUE, BREAST CANCER RESEARCH AND TREATMENT 4: 181 (1984). (10.1007/BF01806483) / BREAST CANCER RESEARCH AND TREATMENT (1984)
BARSKY, S.H., LAMININ MOLECULAR DOMAINS WHICH ALTER METASTASIS IN A MURINE MODEL, JOURNAL OF CLINICAL INVESTIGATION 74: 843 (1984). (10.1172/JCI111501) / JOURNAL OF CLINICAL INVESTIGATION (1984)
BROWN, S.S., CONNECTIN - CELL-SURFACE PROTEIN THAT BINDS BOTH LAMININ AND ACTIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 5927 (1983). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1983)
ENGEL, J, SHAPES, DOMAIN ORGANIZATIONS AND FLEXIBILITY OF LAMININ AND FIBRONECTIN, 2 MULTIFUNCTIONAL PROTEINS OF THE EXTRACELLULAR-MATRIX, JOURNAL OF MOLECULAR BIOLOGY 150: 97 (1981). (10.1016/0022-2836(81)90326-0) / JOURNAL OF MOLECULAR BIOLOGY (1981)
FIDLER, I. J., NATURE-NEW BIOLOGY 242: 148 (1973). (10.1038/newbio242148a0) / NATURE-NEW BIOLOGY (1973)
GRAF, J, IDENTIFICATION OF AN AMINO-ACID-SEQUENCE IN LAMININ MEDIATING CELL ATTACHMENT, CHEMOTAXIS, AND RECEPTOR-BINDING, CELL 48: 989 (1987). (10.1016/0092-8674(87)90707-0) / CELL (1987)
Graf, J., Biochemistry 26: 6896 (1987). (10.1021/bi00396a004) / Biochemistry (1987)
HAND, P.H., EXPRESSION OF LAMININ RECEPTOR IN NORMAL AND CARCINOMATOUS HUMAN-TISSUES AS DEFINED BY A MONOCLONAL-ANTIBODY, CANCER RESEARCH 45: 2713 (1985). / CANCER RESEARCH (1985)
HOWE, C.C., STRUCTURAL-ANALYSIS OF 3 SUBUNITS OF LAMININ FROM TERATOCARCINOMA-DERIVED PARIETAL ENDODERM CELLS, DEVELOPMENTAL BIOLOGY 98: 385 (1983). (10.1016/0012-1606(83)90367-6) / DEVELOPMENTAL BIOLOGY (1983)
10.1126/science.3726541
IWAMOTO Y unpublished data.
KLEINMAN, H.K., BASEMENT-MEMBRANE COMPLEXES WITH BIOLOGICAL-ACTIVITY, BIOCHEMISTRY 25: 312 (1986). (10.1021/bi00350a005) / BIOCHEMISTRY (1986)
KLEINMAN, H.K., BIOLOGICAL-ACTIVITIES OF LAMININ, JOURNAL OF CELLULAR BIOCHEMISTRY 27: 317 (1985). (10.1002/jcb.240270402) / JOURNAL OF CELLULAR BIOCHEMISTRY (1985)
KLEINMAN H.K. unpublished data.
LIOTTA, L.A., TUMOR INVASION AND METASTASES - ROLE OF THE BASEMENT-MEMBRANE - WARNER-LAMBERT PARKE-DAVIS AWARD LECTURE, AMERICAN JOURNAL OF PATHOLOGY 117: 339 (1984). / AMERICAN JOURNAL OF PATHOLOGY (1984)
MALINOFF, H.L., METASTATIC POTENTIAL OF MURINE FIBRO-SARCOMA CELLS IS INFLUENCED BY CELL-SURFACE LAMININ, INTERNATIONAL JOURNAL OF CANCER 33: 651 (1984). (10.1002/ijc.2910330516) / INTERNATIONAL JOURNAL OF CANCER (1984)
MALINOFF, H.L., ISOLATION OF A CELL-SURFACE RECEPTOR PROTEIN FOR LAMININ FROM MURINE FIBRO-SARCOMA CELLS, JOURNAL OF CELL BIOLOGY 96: 1475 (1983). (10.1083/jcb.96.5.1475) / JOURNAL OF CELL BIOLOGY (1983)
MCCOY, J.P., IDENTIFICATION OF A LAMININ-LIKE SUBSTANCE ON THE SURFACE OF HIGH-MALIGNANT MURINE FIBRO-SARCOMA CELLS, JOURNAL OF CELL SCIENCE 65: 139 (1984). (10.1242/jcs.65.1.139) / JOURNAL OF CELL SCIENCE (1984)
PAULSSON, M, EVIDENCE FOR COILED-COIL ALPHA-HELICAL REGIONS IN THE LONG ARM OF LAMININ, EMBO JOURNAL 4: 309 (1985). (10.1002/j.1460-2075.1985.tb03630.x) / EMBO JOURNAL (1985)
REICH R unpublished data.
RUOSLAHTI, E, ARG-GLY-ASP - A VERSATILE CELL RECOGNITION SIGNAL, CELL 44: 517 (1986). (10.1016/0092-8674(86)90259-X) / CELL (1986)
SASAKI, M, SEQUENCE OF THE CDNA-ENCODING THE LAMININ-B1 CHAIN REVEALS A MULTIDOMAIN PROTEIN CONTAINING CYSTEINE-RICH REPEATS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 935 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
TERRANOVA, V.P., ROLE OF LAMININ IN THE ATTACHMENT AND METASTASIS OF MURINE TUMOR-CELLS, CANCER RESEARCH 42: 2265 (1982). / CANCER RESEARCH (1982)
TERRANOVA, V.P., LAMININ RECEPTOR ON HUMAN-BREAST CARCINOMA-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 444 (1983). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1983)
10.1126/science.6505678
TIMPL, R, LAMININ - GLYCOPROTEIN FROM BASEMENT-MEMBRANES, JOURNAL OF BIOLOGICAL CHEMISTRY 254: 9933 (1979). (10.1016/S0021-9258(19)83607-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1979)
TURPEENNIEMIHUJ.T, LAMININ INCREASES THE RELEASE OF TYPE-IV COLLAGENASE FROM MALIGNANT-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 1883 (1986). (10.1016/S0021-9258(17)36025-8) / JOURNAL OF BIOLOGICAL CHEMISTRY (1986)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:38 a.m.)
Indexed	1 month, 2 weeks ago (July 13, 2025, 10:41 p.m.)
Issued	37 years, 9 months ago (Nov. 20, 1987)
Published	37 years, 9 months ago (Nov. 20, 1987)
Published Print	37 years, 9 months ago (Nov. 20, 1987)

Funders 0

None

BibTeX

@article{Iwamoto_1987, title={YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation}, volume={238}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2961059}, DOI={10.1126/science.2961059}, number={4830}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Iwamoto, Yukihide and Robey, Frank A. and Graf, Jeannette and Sasaki, Makoto and Kleinman, Hynda K. and Yamada, Yoshihiko and Martin, George R.}, year={1987}, month=nov, pages={1132–1134} }

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