DOI: 10.1126/science.2922596. Reciprocal Effects of Hyper- and Hypoactivity Mutations in the <i>Drosophila</i> Pattern Gene <i>torso</i>

Reciprocal Effects of Hyper- and Hypoactivity Mutations in the Drosophila Pattern Gene torso

10.1126/science.2922596

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In Drosophila , five "terminal" polarity genes must be active in females in order for them to produce embryos with normal anterior and posterior ends. Hypoactivity mutations in one such gene, torso , result in the loss of the most posterior domain of fushi tarazu expression and the terminal cuticular structures. In contrast, a torso hyperactivity mutation causes the loss of central fushi tarazu expression and central cuticular structures. Cytoplasmic leakage, transplantation, and temperature-shift experiments suggest that the latter effect is caused by abnormal persistence of the torso product in the central region of the embryo during early development. Thus, the amount and timing of torso activity is key to distinguishing the central and terminal regions of the embryo. Mutations in the tailless terminal gene act as dominant maternal suppressors of the hyperactive torso allele, indicating that the torso product acts through, or in concert with, the tailless product.

Bibliography

Strecker, T. R., Halsell, S. R., Fisher, W. W., & Lipshitz, H. D. (1989). Reciprocal Effects of Hyper- and Hypoactivity Mutations in the Drosophila Pattern Gene torso. Science, 243(4894), 1062â1066.

Authors 4

Teresa R. Strecker (first)
Susan R. Halsell (additional)
William W. Fisher (additional)
Howard D. Lipshitz (additional)

References 29 Referenced 72

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:16 a.m.)
Indexed	1 year, 1 month ago (July 10, 2024, 4:32 a.m.)
Issued	36 years, 6 months ago (Feb. 24, 1989)
Published	36 years, 6 months ago (Feb. 24, 1989)
Published Print	36 years, 6 months ago (Feb. 24, 1989)

Funders 0

None

BibTeX

@article{Strecker_1989, title={Reciprocal Effects of Hyper- and Hypoactivity Mutations in the Drosophila Pattern Gene torso}, volume={243}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2922596}, DOI={10.1126/science.2922596}, number={4894}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Strecker, Teresa R. and Halsell, Susan R. and Fisher, William W. and Lipshitz, Howard D.}, year={1989}, month=feb, pages={1062–1066} }

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  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1989,
        2,
        24
      ]
    ]
  },
  "references-count": 29,
  "journal-issue": {
    "issue": "4894",
    "published-print": {
      "date-parts": [
        [
          1989,
          2,
          24
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.2922596"
  ],
  "URL": "http://dx.doi.org/10.1126/science.2922596",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1989,
        2,
        24
      ]
    ]
  }
}