DOI: 10.1126/science.291.5512.2370. Glycosylation and the Immune System

10.1126/science.291.5512.2370

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Almost all of the key molecules involved in the innate and adaptive immune response are glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding, quality control, and assembly of peptide-loaded major histocompatibility complex (MHC) antigens and the T cell receptor complex. Although some glycopeptide antigens are presented by the MHC, the generation of peptide antigens from glycoproteins may require enzymatic removal of sugars before the protein can be cleaved. Oligosaccharides attached to glycoproteins in the junction between T cells and antigen-presenting cells help to orient binding faces, provide protease protection, and restrict nonspecific lateral protein-protein interactions. In the humoral immune system, all of the immunoglobulins and most of the complement components are glycosylated. Although a major function for sugars is to contribute to the stability of the proteins to which they are attached, specific glycoforms are involved in recognition events. For example, in rheumatoid arthritis, an autoimmune disease, agalactosylated glycoforms of aggregated immunoglobulin G may induce association with the mannose-binding lectin and contribute to the pathology.

Bibliography

Rudd, P. M., Elliott, T., Cresswell, P., Wilson, I. A., & Dwek, R. A. (2001). Glycosylation and the Immune System. Science, 291(5512), 2370â2376.

Authors 5

Pauline M. Rudd (first)
Tim Elliott (additional)
Peter Cresswell (additional)
Ian A. Wilson (additional)
Raymond A. Dwek (additional)

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We thank M. Wormald for the molecular modeling D. Shore for preparing Fig. 2 A. Karadimitris for his contribution to the section on CD1 S. J. Davis for his contribution to the section on CD2 and CD48 and D. Wing for careful reading of the manuscript. I.A.W. is supported by NIH grants CA58896 and AI42266. R.A.D. and P.M.R. thank Hilary C. Lister for her constant inspiration.

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:52 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:40 a.m.)
Indexed	3 days, 13 hours ago (Aug. 26, 2025, 2:23 a.m.)
Issued	24 years, 5 months ago (March 23, 2001)
Published	24 years, 5 months ago (March 23, 2001)
Published Print	24 years, 5 months ago (March 23, 2001)

Funders 0

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BibTeX

@article{Rudd_2001, title={Glycosylation and the Immune System}, volume={291}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.291.5512.2370}, DOI={10.1126/science.291.5512.2370}, number={5512}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rudd, Pauline M. and Elliott, Tim and Cresswell, Peter and Wilson, Ian A. and Dwek, Raymond A.}, year={2001}, month=mar, pages={2370–2376} }

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