DOI: 10.1126/science.2904701. Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

10.1126/science.2904701

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The contributions of two subclasses of excitatory amino acid transmitter receptors to the induction and expression of long-term potentiation (LTP) were analyzed in hippocampal slices. The quisqualate/kainate receptor antagonist DNQX (6,7-dinitroquinoxaline-2,3-dione) blocked 85% of the evoked field potential, leaving a small response that was sensitive to D-AP5 (D-2-amino-5-phosphonopentanoate), an N -methyl-D-aspartate (NMDA) receptor blocker. This residual D-AP5-sensitive response was of comparable size in control and previously potentiated inputs. High-frequency stimulation in the presence of DNQX did not result in the development of robust LTP. Washout of the drug, however, revealed the potentiation effect. Thus NMDA-mediated responses can induce, but are not greatly affected by, LTP; non-NMDA receptors, conversely, mediate responses that are not needed to elicit LTP but that are required for its expression.

Bibliography

Muller, D., Joly, M., & Lynch, G. (1988). Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP. Science, 242(4886), 1694â1697.

Authors 3

Dominique Muller (first)
Michel Joly (additional)
Gary Lynch (additional)

References 20 Referenced 391

ASHER, P, J PHYSIOL-LONDON 399: 227 (1988). (10.1113/jphysiol.1988.sp017077) / J PHYSIOL-LONDON (1988)
CHANG, FLF, TRANSIENT AND ENDURING MORPHOLOGICAL CORRELATES OF SYNAPTIC ACTIVITY AND EFFICACY CHANGE IN THE RAT HIPPOCAMPAL SLICE, BRAIN RESEARCH 309: 35 (1984). (10.1016/0006-8993(84)91008-4) / BRAIN RESEARCH (1984)
COLLINGRIDGE, G. L., JOURNAL OF PHYSIOLOGY 334: 33 (1983). (10.1113/jphysiol.1983.sp014478) / JOURNAL OF PHYSIOLOGY (1983)
DOLPHIN, A.C., LONG-TERM POTENTIATION OF THE PERFORANT PATH INVIVO IS ASSOCIATED WITH INCREASED GLUTAMATE RELEASE, NATURE 297: 496 (1982). (10.1038/297496a0) / NATURE (1982)
FAGG, G.E., SELECTIVE ASSOCIATION OF N-METHYL ASPARTATE AND QUISQUALATE TYPES OF L-GLUTAMATE RECEPTOR WITH BRAIN POSTSYNAPTIC DENSITIES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 6876 (1984). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1984)
HARRIS, E.W., LONG-TERM POTENTIATION IN THE HIPPOCAMPUS INVOLVES ACTIVATION OF N-METHYL-D-ASPARTATE RECEPTORS, BRAIN RESEARCH 323: 132 (1984). (10.1016/0006-8993(84)90275-0) / BRAIN RESEARCH (1984)
HERRON, C.E., FREQUENCY-DEPENDENT INVOLVEMENT OF NMDA RECEPTORS IN THE HIPPOCAMPUS - A NOVEL SYNAPTIC MECHANISM, NATURE 322: 265 (1986). (10.1038/322265a0) / NATURE (1986)
10.1126/science.2899909
LARSON, J, ROLE OF N-METHYL-D-ASPARTATE RECEPTORS IN THE INDUCTION OF SYNAPTIC POTENTIATION BY BURST STIMULATION PATTERNED AFTER THE HIPPOCAMPAL O-RHYTHM, BRAIN RESEARCH 441: 111 (1988). (10.1016/0006-8993(88)91388-1) / BRAIN RESEARCH (1988)
LEE, K.S., BRIEF BURSTS OF HIGH-FREQUENCY STIMULATION PRODUCE 2 TYPES OF STRUCTURAL-CHANGE IN RAT HIPPOCAMPUS, JOURNAL OF NEUROPHYSIOLOGY 44: 247 (1980). (10.1152/jn.1980.44.2.247) / JOURNAL OF NEUROPHYSIOLOGY (1980)
MCNAUGHTON, B.L., SYNAPTIC ENHANCEMENT IN FASCIA DENTATA - COOPERATIVITY AMONG COACTIVE AFFERENTS, BRAIN RESEARCH 157: 277 (1978). (10.1016/0006-8993(78)90030-6) / BRAIN RESEARCH (1978)
MONAGHAN, D.T., DISTRIBUTION OF N-METHYL-D-ASPARTATE-SENSITIVE L-[H-3]GLUTAMATE-BINDING SITES IN RAT-BRAIN, JOURNAL OF NEUROSCIENCE 5: 2909 (1985). (10.1523/JNEUROSCI.05-11-02909.1985) / JOURNAL OF NEUROSCIENCE (1985)
MORRIS, RGM, SELECTIVE IMPAIRMENT OF LEARNING AND BLOCKADE OF LONG-TERM POTENTIATION BY AN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, AP5, NATURE 319: 774 (1986). (10.1038/319774a0) / NATURE (1986)
Muller, D., Brain Research 477: 396 (1989). (10.1016/0006-8993(89)91435-2) / Brain Research (1989)
Muller, D., Proceedings of the National Academy of Sciences of the United States of America 85: 9346 (1988). / Proceedings of the National Academy of Sciences of the United States of America (1988)
Muller, D., Synapse 3: 67 (1989). (10.1002/syn.890030110) / Synapse (1989)
NOWAK, L, MAGNESIUM GATES GLUTAMATE-ACTIVATED CHANNELS IN MOUSE CENTRAL NEURONS, NATURE 307: 462 (1984). (10.1038/307462a0) / NATURE (1984)
RAINBOW, T.C., QUANTITATIVE AUTORADIOGRAPHY OF BINDING-SITES FOR [H-3] AMPA, A STRUCTURAL ANALOG OF GLUTAMIC-ACID, BRAIN RESEARCH 309: 173 (1984). (10.1016/0006-8993(84)91025-4) / BRAIN RESEARCH (1984)
Staubli, U., Behavioral Neuroscience 103: 54 (1989). (10.1037/0735-7044.103.1.54) / Behavioral Neuroscience (1989)
WILSON, C.J., PASSIVE CABLE PROPERTIES OF DENDRITIC SPINES AND SPINY NEURONS, JOURNAL OF NEUROSCIENCE 4: 281 (1984). (10.1523/JNEUROSCI.04-01-00281.1984) / JOURNAL OF NEUROSCIENCE (1984)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 5:29 a.m.)
Indexed	2 days, 16 hours ago (Aug. 22, 2025, 12:47 a.m.)
Issued	36 years, 8 months ago (Dec. 23, 1988)
Published	36 years, 8 months ago (Dec. 23, 1988)
Published Print	36 years, 8 months ago (Dec. 23, 1988)

Funders 0

None

BibTeX

@article{Muller_1988, title={Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP}, volume={242}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2904701}, DOI={10.1126/science.2904701}, number={4886}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Muller, Dominique and Joly, Michel and Lynch, Gary}, year={1988}, month=dec, pages={1694–1697} }

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