Actin-Based Plasticity in Dendritic Spines
10.1126/science.290.5492.754
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The central nervous system functions primarily to convert patterns of activity in sensory receptors into patterns of muscle activity that constitute appropriate behavior. At the anatomical level this requires two complementary processes: a set of genetically encoded rules for building the basic network of connections, and a mechanism for subsequently fine tuning these connections on the basis of experience. Identifying the locus and mechanism of these structural changes has long been among neurobiology's major objectives. Evidence has accumulated implicating a particular class of contacts, excitatory synapses made onto dendritic spines, as the sites where connective plasticity occurs. New developments in light microscopy allow changes in spine morphology to be directly visualized in living neurons and suggest that a common mechanism, based on dynamic actin filaments, is involved in both the formation of dendritic spines during development and their structural plasticity at mature synapses.

Bibliography

Matus, A. (2000). Actin-Based Plasticity in Dendritic Spines. Science, 290(5492), 754–758.

Authors 1
  1. Andrew Matus (first)
References 96 Referenced 672
  1. Gray E. G., Nature 183, 1592 (1959). (10.1038/1831592a0) / Nature by Gray E. G. (1959)
  2. Kirov S. A., Harris K. M., Nature Neurosci. 2, 878 (1999). (10.1038/13178) / Nature Neurosci. by Kirov S. A. (1999)
  3. Cragg B. G., J. Anat. 101, 639 (1967). / J. Anat. by Cragg B. G. (1967)
  4. A. Peters S. L. Palay H. d. F. Webster The Fine Structure of the Nervous System (Saunders Philadelphia 1976).
  5. Harris K. M., Kater S. B., Annu. Rev. Neurosci. 17, 341 (1994). (10.1146/annurev.ne.17.030194.002013) / Annu. Rev. Neurosci. by Harris K. M. (1994)
  6. Shepherd G. M., J. Neurophysiol. 75, 2197 (1996). (10.1152/jn.1996.75.6.2197) / J. Neurophysiol. by Shepherd G. M. (1996)
  7. Peters A., Kaiserman-Abramof I. R., Z. Zellforsch. Mikrosk. Anat. 100, 487 (1969). (10.1007/BF00344370) / Z. Zellforsch. Mikrosk. Anat. by Peters A. (1969)
  8. Spacek J., Hartmann M., Anat. Embryol. 167, 289 (1983). (10.1007/BF00298517) / Anat. Embryol. by Spacek J. (1983)
  9. Fiala J. C., Feinberg M., Popov V., Harris K. M., J. Neurosci. 18, 8900 (1998). (10.1523/JNEUROSCI.18-21-08900.1998) / J. Neurosci. by Fiala J. C. (1998)
  10. Matus A., Huber G., Bernhardt R., Cold Spring Harbor Symp. Quant. Biol. 48, 775 (1983). (10.1101/SQB.1983.048.01.079) / Cold Spring Harbor Symp. Quant. Biol. by Matus A. (1983)
  11. Landis D. M., Reese T. S., J. Cell Biol. 97, 1169 (1983). (10.1083/jcb.97.4.1169) / J. Cell Biol. by Landis D. M. (1983)
  12. Fifkova E., Delay R. J., J. Cell Biol. 95, 345 (1982). (10.1083/jcb.95.1.345) / J. Cell Biol. by Fifkova E. (1982)
  13. Matus A., Ackermann M., Pehling G., Byers H. R., Fujiwara K., Proc. Natl. Acad. Sci. U.S.A. 79, 7590 (1982). (10.1073/pnas.79.23.7590) / Proc. Natl. Acad. Sci. U.S.A. by Matus A. (1982)
  14. Cohen R. S., Chung S. K., Pfaff D. W., Cell. Mol. Neurobiol. 5, 271 (1985). (10.1007/BF00711012) / Cell. Mol. Neurobiol. by Cohen R. S. (1985)
  15. Fagg G. E., Matus A., Proc. Natl. Acad. Sci. U.S.A. 81, 6876 (1984). (10.1073/pnas.81.21.6876) / Proc. Natl. Acad. Sci. U.S.A. by Fagg G. E. (1984)
  16. Wu K., Carlin R., Siekevitz P., J. Neurochem. 46, 831 (1986). (10.1111/j.1471-4159.1986.tb13047.x) / J. Neurochem. by Wu K. (1986)
  17. Kornau H. C., Seeburg P. H., Kennedy M. B., Curr. Opin. Neurobiol. 7, 368 (1997). (10.1016/S0959-4388(97)80064-5) / Curr. Opin. Neurobiol. by Kornau H. C. (1997)
  18. Sheng M., Wyszynski M., Bioessays 19, 847 (1997). (10.1002/bies.950191004) / Bioessays by Sheng M. (1997)
  19. Matus A., Curr. Opin. Neurobiol. 9, 561 (1999). (10.1016/S0959-4388(99)00018-5) / Curr. Opin. Neurobiol. by Matus A. (1999)
  20. Garner C. C., Nash J., Huganir R. L., Trends Neurosci. 10, 274 (2000). / Trends Neurosci. by Garner C. C. (2000)
  21. Kaech S., Fisher M., Doll T., Matus A., J. Neurosci. 17, 9565 (1997). (10.1523/JNEUROSCI.17-24-09565.1997) / J. Neurosci. by Kaech S. (1997)
  22. Cooper J. A., Annu. Rev. Physiol. 53, 585 (1991). (10.1146/annurev.ph.53.030191.003101) / Annu. Rev. Physiol. by Cooper J. A. (1991)
  23. D. Bray Cell Movements (Garland New York 1992).
  24. 10.1006/jmbi.1997.1062
  25. 10.1523/JNEUROSCI.16-09-02983.1996
  26. 10.1016/S0896-6273(00)80467-5
  27. 10.1073/pnas.96.23.13438
  28. 10.1038/35009107
  29. Fifkova E., Van Harreveld A., J. Neurocytol. 6, 211 (1977). (10.1007/BF01261506) / J. Neurocytol. by Fifkova E. (1977)
  30. Eccles J. C., Naturwissenschaften 66, 147 (1979). (10.1007/BF00368708) / Naturwissenschaften by Eccles J. C. (1979)
  31. Crick F., Trends Neurosci. 5, 44 (1982). (10.1016/0166-2236(82)90020-0) / Trends Neurosci. by Crick F. (1982)
  32. Carlin R. K., Siekevitz P., Proc. Natl. Acad. Sci U.S.A. 80, 3517 (1983). (10.1073/pnas.80.11.3517) / Proc. Natl. Acad. Sci U.S.A. by Carlin R. K. (1983)
  33. Coss R. G., Perkel D. H., Behav. Neural Biol. 44, 151 (1985). (10.1016/S0163-1047(85)90170-0) / Behav. Neural Biol. by Coss R. G. (1985)
  34. Calverley R. K., Jones D. G., Brain Res. Rev. 15, 215 (1990). (10.1016/0165-0173(90)90002-6) / Brain Res. Rev. by Calverley R. K. (1990)
  35. 10.1515/REVNEURO.1997.8.2.77
  36. Halpain S., Trends Neurosci. 23, 141 (2000). (10.1016/S0166-2236(00)01576-9) / Trends Neurosci. by Halpain S. (2000)
  37. 10.1016/S0092-8674(05)80030-3
  38. 10.1126/science.274.5290.1123
  39. 10.1126/science.179.4071.395
  40. LeVay S., Wiesel T. N., Hubel D. H., J. Comp. Neurol. 191, 1 (1980). (10.1002/cne.901910102) / J. Comp. Neurol. by LeVay S. (1980)
  41. 10.1126/science.274.5290.1133
  42. Feldman D. E., Knudsen E. I., Neuron 20, 1067 (1998). (10.1016/S0896-6273(00)80488-2) / Neuron by Feldman D. E. (1998)
  43. Sharma J., Angelucci A., Sur M., Nature 404, 841 (2000). (10.1038/35009043) / Nature by Sharma J. (2000)
  44. von Melchner L., Pallas S. L., Sur M., Nature 404, 871 (2000). (10.1038/35009102) / Nature by von Melchner L. (2000)
  45. Kaas J. H., Annu. Rev. Neurosci. 14, 137 (1991). (10.1146/annurev.ne.14.030191.001033) / Annu. Rev. Neurosci. by Kaas J. H. (1991)
  46. Gilbert C. D., Curr. Opin. Neurobiol. 3, 100 (1993). (10.1016/0959-4388(93)90042-W) / Curr. Opin. Neurobiol. by Gilbert C. D. (1993)
  47. 10.1146/annurev.neuro.21.1.149
  48. 10.1016/0896-6273(88)90124-9
  49. Lin C. H., Forscher P., J. Cell Biol. 121, 1369 (1993). (10.1083/jcb.121.6.1369) / J. Cell Biol. by Lin C. H. (1993)
  50. Letourneau P. C., Perspect. Dev. Neurobiol. 4, 111 (1996). / Perspect. Dev. Neurobiol. by Letourneau P. C. (1996)
  51. Hu S., Reichardt L. F., Neuron 22, 419 (1999). (10.1016/S0896-6273(00)80696-0) / Neuron by Hu S. (1999)
  52. 10.1016/S0896-6273(00)80283-4
  53. Morest D. K., Z. Anat. Entwicklungsgesch. 128, 290 (1969). (10.1007/BF00522529) / Z. Anat. Entwicklungsgesch. by Morest D. K. (1969)
  54. Bliss T. V., Science 249, 973 (1990). (10.1126/science.2396098) / Science by Bliss T. V. (1990)
  55. 10.1126/science.285.5435.1870
  56. 10.1126/science.283.5409.1923
  57. 10.1038/19978
  58. 10.1038/46574
  59. 10.1523/JNEUROSCI.19-11-04314.1999
  60. 10.1073/pnas.100139797
  61. McKinney R. A., Capogna M., Durr R., Gahwiler B. H., Thompson S. M., Nature Neurosci. 2, 44 (1999). (10.1038/4548) / Nature Neurosci. by McKinney R. A. (1999)
  62. Fischer M., Kaech S., Wagner U., Brinkhaus H., Matus A., Nature Neurosci. 3, 887 (2000). (10.1038/78791) / Nature Neurosci. by Fischer M. (2000)
  63. 10.1038/47507
  64. 10.1038/47501
  65. Muller W., Connor J. A., Nature 354, 73 (1991). (10.1038/354073a0) / Nature by Muller W. (1991)
  66. Guthrie P. B., Segal M., Kater S. B., Nature 354, 76 (1991). (10.1038/354076a0) / Nature by Guthrie P. B. (1991)
  67. Denk W., Sugimori M., Llinas R., Proc. Natl. Acad. Sci. U.S.A. 92, 8279 (1995). (10.1073/pnas.92.18.8279) / Proc. Natl. Acad. Sci. U.S.A. by Denk W. (1995)
  68. Eilers J., Augustine G. J., Konnerth A., Nature 373, 155 (1995). (10.1038/373155a0) / Nature by Eilers J. (1995)
  69. Koester H. J., Sakmann B., Proc. Natl. Acad. Sci. U.S.A. 95, 9596 (1998). (10.1073/pnas.95.16.9596) / Proc. Natl. Acad. Sci. U.S.A. by Koester H. J. (1998)
  70. Wickens J., Prog. Neurobiol. 31, 507 (1988). (10.1016/0301-0082(88)90013-5) / Prog. Neurobiol. by Wickens J. (1988)
  71. 10.1073/pnas.87.17.6718
  72. Koch C., Zador A., J. Neurosci. 13, 413 (1993). (10.1523/JNEUROSCI.13-02-00413.1993) / J. Neurosci. by Koch C. (1993)
  73. 10.1038/375682a0
  74. Denk W., Yuste R., Svoboda K., Tank D. W., Curr. Opin. Neurobiol. 6, 372 (1996). (10.1016/S0959-4388(96)80122-X) / Curr. Opin. Neurobiol. by Denk W. (1996)
  75. Matus A., Brinkhaus H., Wagner U., Hippocampus 10, 551 (2000). (10.1002/1098-1063(2000)10:5<555::AID-HIPO5>3.0.CO;2-Z) / Hippocampus by Matus A. (2000)
  76. 10.1523/JNEUROSCI.18-07-02423.1998
  77. Choi D. W., Prog. Brain Res. 100, 47 (1994). (10.1016/S0079-6123(08)60767-0) / Prog. Brain Res. by Choi D. W. (1994)
  78. Rothman S. M., Olney J. W., Trends Neurosci. 18, 57 (1995). / Trends Neurosci. by Rothman S. M. (1995)
  79. Halpain S., Hipolito A., Saffer L., J. Neurosci. 18, 9835 (1998). (10.1523/JNEUROSCI.18-23-09835.1998) / J. Neurosci. by Halpain S. (1998)
  80. Liao D., Hessler N. A., Malinow R., Nature 375, 400 (1995). (10.1038/375400a0) / Nature by Liao D. (1995)
  81. Durand G. M., Kovalchuk Y., Konnerth A., Nature 381, 71 (1996). (10.1038/381071a0) / Nature by Durand G. M. (1996)
  82. Isaac J. T., Crair M. C., Nicoll R. A., Malenka R. C., Neuron 18, 269 (1997). (10.1016/S0896-6273(00)80267-6) / Neuron by Isaac J. T. (1997)
  83. D. Liao X. Zhang R. O'Brien
  84. Ehlers M. D., Huganir R. L., Nature Neurosci. 2, 37 (1999). (10.1038/4540) / Nature Neurosci. by Ehlers M. D. (1999)
  85. Petralia R. S., et al., Nature Neurosci. 2, 31 (1999). (10.1038/4532) / Nature Neurosci. by Petralia R. S. (1999)
  86. 10.1126/science.284.5421.1811
  87. 10.1016/S0896-6273(00)00003-9
  88. Parnavelas J. G., Lynch G., Brecha N., Cotman C. W., Globus A., Nature 248, 71 (1974). (10.1038/248071a0) / Nature by Parnavelas J. G. (1974)
  89. Herndon R. M., Margolis G., Kilham L., J. Neuropathol. Exp. Neurol. 30, 557 (1971). (10.1097/00005072-197110000-00001) / J. Neuropathol. Exp. Neurol. by Herndon R. M. (1971)
  90. Hirano A., J. Neural Transm. Suppl. 18, 1 (1983). / J. Neural Transm. Suppl. by Hirano A. (1983)
  91. Sotelo C., J. Exp. Biol. 153, 225 (1990). (10.1242/jeb.153.1.225) / J. Exp. Biol. by Sotelo C. (1990)
  92. 10.1016/S0896-6273(00)80785-0
  93. Gilbert C. D., Cereb. Cortex 3, 373 (1993). (10.1093/cercor/3.5.373) / Cereb. Cortex by Gilbert C. D. (1993)
  94. Rauschecker J. P., Trends Neurosci. 22, 74 (1999). (10.1016/S0166-2236(98)01303-4) / Trends Neurosci. by Rauschecker J. P. (1999)
  95. Jenkins W. M., Merzenich M. M., Ochs M. T., Allard T., Guic-Robles E., J. Neurophysiol. 63, 82 (1990). (10.1152/jn.1990.63.1.82) / J. Neurophysiol. by Jenkins W. M. (1990)
  96. Pascual-Leone A., Torres F., Brain 116, 39 (1993). (10.1093/brain/116.1.39) / Brain by Pascual-Leone A. (1993)
Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 1:47 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 12:45 a.m.)
Indexed 1 month ago (July 27, 2025, 3:29 a.m.)
Issued 24 years, 10 months ago (Oct. 27, 2000)
Published 24 years, 10 months ago (Oct. 27, 2000)
Published Print 24 years, 10 months ago (Oct. 27, 2000)
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