DOI: 10.1126/science.2897717. Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin

Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin

10.1126/science.2897717

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase δ. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression.

Bibliography

Jaskulski, D., deRiel, J. K., Mercer, W. E., Calabretta, B., & Baserga, R. (1988). Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin. Science, 240(4858), 1544â1546.

Authors 5

Dariusz Jaskulski (first)
J. Kim deRiel (additional)
W. Edward Mercer (additional)
Bruno Calabretta (additional)
Renato Baserga (additional)

References 18 Referenced 307

ALMENDRAL, J.M., CLONING AND SEQUENCE OF THE HUMAN NUCLEAR-PROTEIN CYCLIN - HOMOLOGY WITH DNA-BINDING PROTEINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 1575 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
BIANCHI, V, REGULATION OF PYRIMIDINE DEOXYRIBONUCLEOTIDE METABOLISM BY SUBSTRATE CYCLES IN DCMP DEAMINASE-DEFICIENT V79 HAMSTER-CELLS, MOLECULAR AND CELLULAR BIOLOGY 7: 4218 (1987). / MOLECULAR AND CELLULAR BIOLOGY (1987)
BRAVO, R, SYNTHESIS OF THE NUCLEAR-PROTEIN CYCLIN (PCNA) AND ITS RELATIONSHIP WITH DNA-REPLICATION, EXPERIMENTAL CELL RESEARCH 163: 287 (1986). (10.1016/0014-4827(86)90059-5) / EXPERIMENTAL CELL RESEARCH (1986)
BRAVO, R, EXISTENCE OF 2 POPULATIONS OF CYCLIN PROLIFERATING CELL NUCLEAR ANTIGEN DURING THE CELL-CYCLE - ASSOCIATION WITH DNA-REPLICATION SITES, JOURNAL OF CELL BIOLOGY 105: 1549 (1987). (10.1083/jcb.105.4.1549) / JOURNAL OF CELL BIOLOGY (1987)
BRAVO, R, CYCLIN PCNA IS THE AUXILIARY PROTEIN OF DNA POLYMERASE-DELTA, NATURE 326: 515 (1987). (10.1038/326515a0) / NATURE (1987)
HAMMOND, R.A., IDENTIFICATION OF DNA POLYMERASE-DELTA IN CV-1 CELLS - STUDIES IMPLICATING BOTH DNA POLYMERASE-DELTA AND DNA POLYMERASE-ALPHA IN DNA-REPLICATION, BIOCHEMISTRY 26: 6817 (1987). (10.1021/bi00395a035) / BIOCHEMISTRY (1987)
HEIKKILA, R, A C-MYC ANTISENSE OLIGODEOXYNUCLEOTIDE INHIBITS ENTRY INTO S-PHASE BUT NOT PROGRESS FROM G0 TO G1, NATURE 328: 445 (1987). (10.1038/328445a0) / NATURE (1987)
HOLT, J.T., AN OLIGOMER COMPLEMENTARY TO C-MYC MESSENGER-RNA INHIBITS PROLIFERATION OF HL-60 PROMYELOCYTIC CELLS AND INDUCES DIFFERENTIATION, MOLECULAR AND CELLULAR BIOLOGY 8: 963 (1988). / MOLECULAR AND CELLULAR BIOLOGY (1988)
HOLT, J.T., INDUCIBLE PRODUCTION OF C-FOS ANTISENSE RNA INHIBITS 3T3 CELL-PROLIFERATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 4794 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
Jaskulski, D., Journal of Biological Chemistry 263: 10175 (1988). (10.1016/S0021-9258(19)81493-X) / Journal of Biological Chemistry (1988)
JASKULSKI D unpublished data.
10.1126/science.3726533
MARCUS P COMMUNICATION.
MATHEWS, M.B., IDENTITY OF THE PROLIFERATING CELL NUCLEAR ANTIGEN AND CYCLIN, NATURE 309: 374 (1984). (10.1038/309374a0) / NATURE (1984)
MERCER, W.E., ROLE OF THE P53-PROTEIN IN CELL-PROLIFERATION AS STUDIED BY MICROINJECTION OF MONOCLONAL-ANTIBODIES, MOLECULAR AND CELLULAR BIOLOGY 4: 276 (1984). / MOLECULAR AND CELLULAR BIOLOGY (1984)
MIYACHI, K, AUTOANTIBODY TO A NUCLEAR ANTIGEN IN PROLIFERATING CELLS, JOURNAL OF IMMUNOLOGY 121: 2228 (1978). (10.4049/jimmunol.121.6.2228) / JOURNAL OF IMMUNOLOGY (1978)
OKAYAMA, H, A CDNA CLONING VECTOR THAT PERMITS EXPRESSION OF CDNA INSERTS IN MAMMALIAN-CELLS, MOLECULAR AND CELLULAR BIOLOGY 3: 280 (1983). / MOLECULAR AND CELLULAR BIOLOGY (1983)
PRELICH, G, THE CELL-CYCLE REGULATED PROLIFERATING CELL NUCLEAR ANTIGEN IS REQUIRED FOR SV40-DNA REPLICATION INVITRO, NATURE 326: 471 (1987). (10.1038/326471a0) / NATURE (1987)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:52 a.m.)
Indexed	3 weeks, 1 day ago (Aug. 5, 2025, 8:27 a.m.)
Issued	37 years, 2 months ago (June 10, 1988)
Published	37 years, 2 months ago (June 10, 1988)
Published Print	37 years, 2 months ago (June 10, 1988)

Funders 0

None

BibTeX

@article{Jaskulski_1988, title={Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin}, volume={240}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2897717}, DOI={10.1126/science.2897717}, number={4858}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Jaskulski, Dariusz and deRiel, J. Kim and Mercer, W. Edward and Calabretta, Bruno and Baserga, Renato}, year={1988}, month=jun, pages={1544–1546} }

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