DOI: 10.1126/science.2889267. Clonal Analysis of Human Colorectal Tumors

Clonal Analysis of Human Colorectal Tumors

10.1126/science.2889267

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The clonal composition of human colorectal tumors was studied by means of restriction fragment length polymorphisms (RFLPs). First, X-linked RFLPs were used to examine the pattern of X chromosome inactivation in colorectal tumors of females. All 50 tumors examined showed monoclonal patterns of X chromosome inactivation; these tumors included 20 carcinomas as well as 30 adenomas of either familial or spontaneous type. Second, RFLPs of autosomes were used as clonal markers to detect the somatic loss or gain of specific chromosomal sequences in colorectal tumors. Among other changes, it was found that somatic loss of chromosome 17p sequences occurred in over 75 percent of the carcinomas examined, but such loss was rare in adenomas. These data support a monoclonal origin for colorectal neoplasms, and suggest that a gene on the short arm of chromosome 17 may be associated with progression from the benign to the malignant state.

Bibliography

Fearon, E. R., Hamilton, S. R., & Vogelstein, B. (1987). Clonal Analysis of Human Colorectal Tumors. Science, 238(4824), 193â197.

Authors 3

Eric R. Fearon (first)
Stanley R. Hamilton (additional)
Bert Vogelstein (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:39 a.m.)
Indexed	1 month ago (Aug. 2, 2025, 12:52 a.m.)
Issued	37 years, 10 months ago (Oct. 9, 1987)
Published	37 years, 10 months ago (Oct. 9, 1987)
Published Print	37 years, 10 months ago (Oct. 9, 1987)

Funders 0

None

BibTeX

@article{Fearon_1987, title={Clonal Analysis of Human Colorectal Tumors}, volume={238}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2889267}, DOI={10.1126/science.2889267}, number={4824}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Fearon, Eric R. and Hamilton, Stanley R. and Vogelstein, Bert}, year={1987}, month=oct, pages={193–197} }

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