DOI: 10.1126/science.288.5470.1379. Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids

Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids

10.1126/science.288.5470.1379

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In eukaryotic cells, sister DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of sister chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's subunits may trigger sister separation at the onset of anaphase.

Bibliography

Nasmyth, K., Peters, J.-M., & Uhlmann, F. (2000). Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids. Science, 288(5470), 1379â1384.

Authors 3

Kim Nasmyth (first)
Jan-Michael Peters (additional)
Frank Uhlmann (additional)

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We thank E. Koonin for first pointing out the conserved His and Cys residues in the separin sequences. We also thank K. Nagao I. Sumara S. Hauf I. Waizenegger and M. Yanagida for communicating unpublished results; D. Schweizer and H. Tkadletz for help with the figures; A. Bajer H. Erickson C. Lehner J. Mole-Bajer C. Rieder and A. Sumner for providing micrographs; S. Vrba for library support; and M. Glotzer C. Lehner A. Nasmyth C. Rieder D. Schweizer and T. Skern for discussions and comments on the manuscript. Supported by grants from the Austrian Industrial Research Promotion Fund (FFF) and the Austrian Science Promotion Fund (FWF) to K.N. and J.-M.P.

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:48 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 5:50 a.m.)
Indexed	3 weeks, 4 days ago (Aug. 7, 2025, 4:45 p.m.)
Issued	25 years, 3 months ago (May 26, 2000)
Published	25 years, 3 months ago (May 26, 2000)
Published Print	25 years, 3 months ago (May 26, 2000)

Funders 0

None

BibTeX

@article{Nasmyth_2000, title={Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids}, volume={288}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.288.5470.1379}, DOI={10.1126/science.288.5470.1379}, number={5470}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Nasmyth, Kim and Peters, Jan-Michael and Uhlmann, Frank}, year={2000}, month=may, pages={1379–1384} }

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      "unstructured": "We thank E. Koonin for first pointing out the conserved His and Cys residues in the separin sequences. We also thank K. Nagao I. Sumara S. Hauf I. Waizenegger and M. Yanagida for communicating unpublished results; D. Schweizer and H. Tkadletz for help with the figures; A. Bajer H. Erickson C. Lehner J. Mole-Bajer C. Rieder and A. Sumner for providing micrographs; S. Vrba for library support; and M. Glotzer C. Lehner A. Nasmyth C. Rieder D. Schweizer and T. Skern for discussions and comments on the manuscript. Supported by grants from the Austrian Industrial Research Promotion Fund (FFF) and the Austrian Science Promotion Fund (FWF) to K.N. and J.-M.P."
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