Seeing the Herpesvirus Capsid at 8.5 Å
10.1126/science.288.5467.877
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Human herpesviruses are large and structurally complex viruses that cause a variety of diseases. The three-dimensional structure of the herpesvirus capsid has been determined at 8.5 angstrom resolution by electron cryomicroscopy. More than 30 putative α helices were identified in the four proteins that make up the 0.2 billion–dalton shell. Some of these helices are located at domains that undergo conformational changes during capsid assembly and DNA packaging. The unique spatial arrangement of the heterotrimer at the local threefold positions accounts for the asymmetric interactions with adjacent capsid components and the unusual co-dependent folding of its subunits.

Bibliography

Zhou, Z. H., Dougherty, M., Jakana, J., He, J., Rixon, F. J., & Chiu, W. (2000). Seeing the Herpesvirus Capsid at 8.5 Å. Science, 288(5467), 877–880.

Authors 6
  1. Z. Hong Zhou (first)
  2. Matthew Dougherty (additional)
  3. Joanita Jakana (additional)
  4. Jing He (additional)
  5. Frazer J. Rixon (additional)
  6. Wah Chiu (additional)
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  36. Supported by NIH National Center for Research Resources NSF and the Human Frontier Science Program. Z.H.Z. is a Pew Scholar in Biomedical Sciences and a Basil O'Connor Starter Scholar of the March of Dimes Birth Defects Foundation. We thank M. F. Schmid for discussions.
Dates
Type When
Created 23 years ago (July 27, 2002, 5:48 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 5:04 a.m.)
Indexed 1 week, 2 days ago (Aug. 12, 2025, 6:20 p.m.)
Issued 25 years, 3 months ago (May 5, 2000)
Published 25 years, 3 months ago (May 5, 2000)
Published Print 25 years, 3 months ago (May 5, 2000)
Funders 0

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@article{Zhou_2000, title={Seeing the Herpesvirus Capsid at 8.5 Å}, volume={288}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.288.5467.877}, DOI={10.1126/science.288.5467.877}, number={5467}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Zhou, Z. Hong and Dougherty, Matthew and Jakana, Joanita and He, Jing and Rixon, Frazer J. and Chiu, Wah}, year={2000}, month=may, pages={877–880} }