Comparative Genomics of the Eukaryotes
10.1126/science.287.5461.2204
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

A comparative analysis of the genomes of Drosophila melanogaster , Caenorhabditis elegans , and Saccharomyces cerevisiae —and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

Bibliography

Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., Fleischmann, W., Cherry, J. M., Henikoff, S., Skupski, M. P., Misra, S., Ashburner, M., Birney, E., Boguski, M. S., Brody, T., … Lewis, S. (2000). Comparative Genomics of the Eukaryotes. Science, 287(5461), 2204–2215.

Authors 56 University of Pennsylvania
  1. Gerald M. Rubin (first)
  2. Mark D. Yandell (additional)
  3. Jennifer R. Wortman (additional)
  4. George L. Gabor (additional)
  5. Miklos (additional)
  6. Catherine R. Nelson (additional)
  7. Iswar K. Hariharan (additional)
  8. Mark E. Fortini (additional) University of Pennsylvania
  9. Peter W. Li (additional)
  10. Rolf Apweiler (additional)
  11. Wolfgang Fleischmann (additional)
  12. J. Michael Cherry (additional)
  13. Steven Henikoff (additional)
  14. Marian P. Skupski (additional)
  15. Sima Misra (additional)
  16. Michael Ashburner (additional)
  17. Ewan Birney (additional)
  18. Mark S. Boguski (additional)
  19. Thomas Brody (additional)
  20. Peter Brokstein (additional)
  21. Susan E. Celniker (additional)
  22. Stephen A. Chervitz (additional)
  23. David Coates (additional)
  24. Anibal Cravchik (additional)
  25. Andrei Gabrielian (additional)
  26. Richard F. Galle (additional)
  27. William M. Gelbart (additional)
  28. Reed A. George (additional)
  29. Lawrence S. B. Goldstein (additional)
  30. Fangcheng Gong (additional)
  31. Ping Guan (additional)
  32. Nomi L. Harris (additional)
  33. Bruce A. Hay (additional)
  34. Roger A. Hoskins (additional)
  35. Jiayin Li (additional)
  36. Zhenya Li (additional)
  37. Richard O. Hynes (additional)
  38. S. J. M. Jones (additional)
  39. Peter M. Kuehl (additional)
  40. Bruno Lemaitre (additional)
  41. J. Troy Littleton (additional)
  42. Deborah K. Morrison (additional)
  43. Chris Mungall (additional)
  44. Patrick H. O'Farrell (additional)
  45. Oxana K. Pickeral (additional)
  46. Chris Shue (additional)
  47. Leslie B. Vosshall (additional)
  48. Jiong Zhang (additional)
  49. Qi Zhao (additional)
  50. Xiangqun H. Zheng (additional)
  51. Fei Zhong (additional)
  52. Wenyan Zhong (additional)
  53. Richard Gibbs (additional)
  54. J. Craig Venter (additional)
  55. Mark D. Adams (additional)
  56. Suzanna Lewis (additional)
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  96. The many participants from academic institutions are grateful for their various sources of support. Participants from the Berkeley Drosophila Genome Project are supported by NIH grant P50HG00750 (G.M.R.) and grant P4IHG00739 (W.M.G.).
Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 1:35 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 12:48 a.m.)
Indexed 1 week, 4 days ago (Aug. 21, 2025, 12:59 p.m.)
Issued 25 years, 5 months ago (March 24, 2000)
Published 25 years, 5 months ago (March 24, 2000)
Published Print 25 years, 5 months ago (March 24, 2000)
Funders 0

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@article{Rubin_2000, title={Comparative Genomics of the Eukaryotes}, volume={287}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.287.5461.2204}, DOI={10.1126/science.287.5461.2204}, number={5461}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rubin, Gerald M. and Yandell, Mark D. and Wortman, Jennifer R. and Gabor, George L. and Miklos and Nelson, Catherine R. and Hariharan, Iswar K. and Fortini, Mark E. and Li, Peter W. and Apweiler, Rolf and Fleischmann, Wolfgang and Cherry, J. Michael and Henikoff, Steven and Skupski, Marian P. and Misra, Sima and Ashburner, Michael and Birney, Ewan and Boguski, Mark S. and Brody, Thomas and Brokstein, Peter and Celniker, Susan E. and Chervitz, Stephen A. and Coates, David and Cravchik, Anibal and Gabrielian, Andrei and Galle, Richard F. and Gelbart, William M. and George, Reed A. and Goldstein, Lawrence S. B. and Gong, Fangcheng and Guan, Ping and Harris, Nomi L. and Hay, Bruce A. and Hoskins, Roger A. and Li, Jiayin and Li, Zhenya and Hynes, Richard O. and Jones, S. J. M. and Kuehl, Peter M. and Lemaitre, Bruno and Littleton, J. Troy and Morrison, Deborah K. and Mungall, Chris and O’Farrell, Patrick H. and Pickeral, Oxana K. and Shue, Chris and Vosshall, Leslie B. and Zhang, Jiong and Zhao, Qi and Zheng, Xiangqun H. and Zhong, Fei and Zhong, Wenyan and Gibbs, Richard and Venter, J. Craig and Adams, Mark D. and Lewis, Suzanna}, year={2000}, month=mar, pages={2204–2215} }