Out of Eden: Stem Cells and Their Niches
10.1126/science.287.5457.1427
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.

Bibliography

Watt, F. M., & Hogan, and B. L. M. (2000). Out of Eden: Stem Cells and Their Niches. Science, 287(5457), 1427–1430.

Authors 2
  1. Fiona M. Watt (first)
  2. and Brigid L. M. Hogan (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:40 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 5:18 a.m.)
Indexed 4 days, 13 hours ago (Aug. 24, 2025, 6:52 p.m.)
Issued 25 years, 6 months ago (Feb. 25, 2000)
Published 25 years, 6 months ago (Feb. 25, 2000)
Published Print 25 years, 6 months ago (Feb. 25, 2000)
Funders 0

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@article{Watt_2000, title={Out of Eden: Stem Cells and Their Niches}, volume={287}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.287.5457.1427}, DOI={10.1126/science.287.5457.1427}, number={5457}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Watt, Fiona M. and Hogan, and Brigid L. M.}, year={2000}, month=feb, pages={1427–1430} }