Organizing Principles for a Diversity of GABAergic Interneurons and Synapses in the Neocortex
10.1126/science.287.5451.273
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

A puzzling feature of the neocortex is the rich array of inhibitory interneurons. Multiple neuron recordings revealed numerous electrophysiological-anatomical subclasses of neocortical γ-aminobutyric acid–ergic (GABAergic) interneurons and three types of GABAergic synapses. The type of synapse used by each interneuron to influence its neighbors follows three functional organizing principles. These principles suggest that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable combinatorial inhibitory effects in the neocortex.

Bibliography

Gupta, A., Wang, Y., & Markram, H. (2000). Organizing Principles for a Diversity of GABAergic Interneurons and Synapses in the Neocortex. Science, 287(5451), 273–278.

Authors 3
  1. Anirudh Gupta (first)
  2. Yun Wang (additional)
  3. Henry Markram (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:45 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 5:07 a.m.)
Indexed 1 month, 3 weeks ago (July 7, 2025, 2:27 a.m.)
Issued 25 years, 7 months ago (Jan. 14, 2000)
Published 25 years, 7 months ago (Jan. 14, 2000)
Published Print 25 years, 7 months ago (Jan. 14, 2000)
Funders 0

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@article{Gupta_2000, title={Organizing Principles for a Diversity of GABAergic Interneurons and Synapses in the Neocortex}, volume={287}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.287.5451.273}, DOI={10.1126/science.287.5451.273}, number={5451}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Gupta, Anirudh and Wang, Yun and Markram, Henry}, year={2000}, month=jan, pages={273–278} }