DOI: 10.1126/science.2861660. Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

10.1126/science.2861660

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.

Bibliography

Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Buchanan, K., & Johnston, M. V. (1985). Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor. Science, 229(4710), 284â287.

Authors 5

William C. Mobley (first)
J. Lynn Rutkowski (additional)
Gihan I. Tennekoon (additional)
Karen Buchanan (additional)
Michael V. Johnston (additional)

References 60 Referenced 401

APPEL, S.H., A UNIFYING HYPOTHESIS FOR THE CAUSE OF AMYOTROPHIC LATERAL SCLEROSIS, PARKINSONISM, AND ALZHEIMER-DISEASE, ANNALS OF NEUROLOGY 10: 499 (1981). (10.1002/ana.410100602) / ANNALS OF NEUROLOGY (1981)
AQUILONIUS, S.M., REGIONAL DISTRIBUTION OF CHOLINE-ACETYLTRANSFERASE IN HUMAN BRAIN - CHANGES IN HUNTINGTONS-CHOREA, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 38: 669 (1975). (10.1136/jnnp.38.7.669) / JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (1975)
AVRITH, D.B., RENIN-LIKE EFFECTS OF NGF EVALUATED USING RENIN-ANGIOTENSIN ANTAGONISTS, NATURE 285: 248 (1980). (10.1038/285248a0) / NATURE (1980)
BARDE, Y.A., NEW NEUROTROPHIC FACTORS, ANNUAL REVIEW OF PHYSIOLOGY 45: 601 (1983). (10.1146/annurev.ph.45.030183.003125) / ANNUAL REVIEW OF PHYSIOLOGY (1983)
BERG, D.K., NEW NEURONAL GROWTH-FACTORS, ANNUAL REVIEW OF NEUROSCIENCE 7: 149 (1984). (10.1146/annurev.ne.07.030184.001053) / ANNUAL REVIEW OF NEUROSCIENCE (1984)
BIRD, E.D., HUNTINGTONS-CHOREA - POSTMORTEM MEASUREMENT OF GLUTAMIC-ACID DECARBOXYLASE, CHOLINE-ACETYLTRANSFERASE AND DOPAMINE IN BASAL GANGLIA, BRAIN 97: 457 (1974). (10.1093/brain/97.1.457) / BRAIN (1974)
BOLAM, J.P., CHARACTERIZATION OF CHOLINERGIC NEURONS IN THE RAT NEOSTRIATUM - A COMBINATION OF CHOLINE-ACETYLTRANSFERASE IMMUNOCYTOCHEMISTRY, GOLGI-IMPREGNATION AND ELECTRON-MICROSCOPY, NEUROSCIENCE 12: 711 (1984). (10.1016/0306-4522(84)90165-9) / NEUROSCIENCE (1984)
BRUYN, G.W., HDB CLINICAL NEUROLO 6: 298 (1968). / HDB CLINICAL NEUROLO (1968)
CARSTAIRS, J.R., IMMUNOGENIC CONTAMINANTS IN MOUSE NERVE-GROWTH FACTOR, EUROPEAN JOURNAL OF BIOCHEMISTRY 77: 311 (1977). (10.1111/j.1432-1033.1977.tb11669.x) / EUROPEAN JOURNAL OF BIOCHEMISTRY (1977)
COYLE, J.T., BASIC NEUROCHEMISTRY: 205 (1981). / BASIC NEUROCHEMISTRY (1981)
COZZARI, C, SEPARATION OF ISORENIN ACTIVITY FROM NERVE GROWTH-FACTOR (NGF) ACTIVITY IN MOUSE SUBMAXILLARY-GLAND EXTRACTS, BIOCHEMICAL PHARMACOLOGY 22: 1321 (1973). (10.1016/0006-2952(73)90306-7) / BIOCHEMICAL PHARMACOLOGY (1973)
10.1126/science.7089542
CRUTCHER, M.D., SINGLE CELL STUDIES OF THE PRIMATE PUTAMEN .2. RELATIONS TO DIRECTION OF MOVEMENT AND PATTERN OF MUSCULAR-ACTIVITY, EXPERIMENTAL BRAIN RESEARCH 53: 244 (1984). (10.1007/BF00238154) / EXPERIMENTAL BRAIN RESEARCH (1984)
DARLING, T.L., CELL CULTURE METHODS 4: 79 (1984). / CELL CULTURE METHODS (1984)
10.1152/jn.1971.34.3.414
FRAZIER, W.A., SPECIFIC BINDING-SITES FOR I-125-NERVE GROWTH-FACTOR IN PERIPHERAL TISSUES AND BRAIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 57: 1096 (1974). (10.1016/0006-291X(74)90809-2) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1974)
FRAZIER, W.A., PROPERTIES AND SPECIFICITY OF BINDING-SITES FOR I-125 NERVE GROWTH-FACTOR IN EMBRYONIC HEART AND BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 5918 (1974). (10.1016/S0021-9258(20)79906-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1974)
GNAHN, H, NGF-MEDIATED INCREASE OF CHOLINE-ACETYLTRANSFERASE (CHAT) IN THE NEONATAL RAT FOREBRAIN - EVIDENCE FOR A PHYSIOLOGICAL-ROLE OF NGF IN THE BRAIN, DEVELOPMENTAL BRAIN RESEARCH 9: 45 (1983). (10.1016/0165-3806(83)90107-4) / DEVELOPMENTAL BRAIN RESEARCH (1983)
GREENE, L.A., NERVE GROWTH-FACTOR - BIOCHEMISTRY, SYNTHESIS, AND MECHANISM OF ACTION, ANNUAL REVIEW OF NEUROSCIENCE 3: 353 (1980). (10.1146/annurev.ne.03.030180.002033) / ANNUAL REVIEW OF NEUROSCIENCE (1980)
GREENE, L.A., NEUROBIOLOGY 1: 37 (1971). / NEUROBIOLOGY (1971)
GUROFF, G, INDUCTION OF ORNITHINE DECARBOXYLASE BY RENIN-FREE NERVE GROWTH-FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77: 4607 (1980). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1980)
HABER, E, APPLICATION OF A RADIOIMMUNOASSAY FOR ANGIOTENSIN I TO PHYSIOLOGIC MEASUREMENTS OF PLASMA RENIN ACTIVITY IN NORMAL HUMAN SUBJECTS, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 29: 1349 (1969). (10.1210/jcem-29-10-1349) / JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (1969)
HARPER, G.P., TARGET-CELLS, BIOLOGICAL EFFECTS, AND MECHANISM OF ACTION OF NERVE GROWTH-FACTOR AND ITS ANTIBODIES, ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 21: 205 (1981). (10.1146/annurev.pa.21.040181.001225) / ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (1981)
HARPER, G.P., BIOLOGICAL AND IMMUNOLOGICAL PROPERTIES OF THE NERVE GROWTH-FACTOR FROM BOVINE SEMINAL PLASMA - COMPARISON WITH THE PROPERTIES OF MOUSE NERVE GROWTH-FACTOR, NEUROSCIENCE 8: 375 (1983). (10.1016/0306-4522(83)90073-8) / NEUROSCIENCE (1983)
HEFTI, F, CHRONIC INTRAVENTRICULAR-INJECTIONS OF NERVE GROWTH-FACTOR ELEVATE HIPPOCAMPAL CHOLINE-ACETYLTRANSFERASE ACTIVITY IN ADULT-RATS WITH PARTIAL SEPTO-HIPPOCAMPAL LESIONS, BRAIN RESEARCH 293: 305 (1984). (10.1016/0006-8993(84)91237-X) / BRAIN RESEARCH (1984)
HEFTI, F, NERVE GROWTH-FACTOR INCREASES CHOLINE ACETYL-TRANSFERASE BUT NOT SURVIVAL OR FIBER OUTGROWTH OF CULTURED FETAL SEPTAL CHOLINERGIC NEURONS, NEUROSCIENCE 14: 55 (1985). (10.1016/0306-4522(85)90163-0) / NEUROSCIENCE (1985)
HONEGGER, P, NERVE GROWTH-FACTOR (NGF) STIMULATION OF CHOLINERGIC TELENCEPHALIC NEURONS IN AGGREGATING CELL-CULTURES, DEVELOPMENTAL BRAIN RESEARCH 3: 229 (1982). (10.1016/0165-3806(82)90023-2) / DEVELOPMENTAL BRAIN RESEARCH (1982)
HUNTER, W.M., PREPARATION OF IODINE-131 LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC ACTIVITY, NATURE 194: 495 (1962). (10.1038/194495a0) / NATURE (1962)
JOHNSON, E.M., DORSAL-ROOT GANGLION NEURONS ARE DESTROYED BY EXPOSURE IN UTERO TO MATERNAL ANTIBODY TO NERVE GROWTH-FACTOR, SCIENCE 210: 916 (1980). (10.1126/science.7192014) / SCIENCE (1980)
JOHNSTON, M.V., NEOCORTICAL CHOLINERGIC INNERVATION - A DESCRIPTION OF EXTRINSIC AND INTRINSIC COMPONENTS IN THE RAT, EXPERIMENTAL BRAIN RESEARCH 43: 159 (1981). / EXPERIMENTAL BRAIN RESEARCH (1981)
KLAWANS, H.L., CENTRAL CHOLINERGIC-ANTICHOLINERGIC ANTAGONISM IN HUNTINGTONS-CHOREA, NEUROLOGY 22: 107 (1972). (10.1212/WNL.22.2.107) / NEUROLOGY (1972)
KORSCHING, S, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 10: 1056 (1984). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1984)
10.1038/227680a0
LAKSHMANAN, J, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 10: 1049 (1984). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1984)
10.1152/physrev.1968.48.3.534
LEWIS, M.E., SHORT-LATENCY DRINKING AND INCREASED NA APPETITE AFTER INTRA-CEREBRAL MICRO-INJECTIONS OF NGF IN RATS, NATURE 279: 440 (1979). (10.1038/279440a0) / NATURE (1979)
LINDSAY, R.M., ADULT-RAT BRAIN ASTROCYTES SUPPORT SURVIVAL OF BOTH NGF-DEPENDENT AND NGF-INSENSITIVE NEURONS, NATURE 282: 80 (1979). (10.1038/282080a0) / NATURE (1979)
10.1016/S0021-9258(19)52451-6
MACINTOSH, F.C., BASIC NEUROCHEMISTRY: 183 (1981). / BASIC NEUROCHEMISTRY (1981)
MCCAUGHEY, WTE, THE PATHOLOGIC SPECTRUM OF HUNTINGTONS-CHOREA, JOURNAL OF NERVOUS AND MENTAL DISEASE 133: 91 (1961). (10.1097/00005053-196108000-00001) / JOURNAL OF NERVOUS AND MENTAL DISEASE (1961)
MCGEER, P.L., BASIC NEUROCHEMISTRY: 233 (1981). / BASIC NEUROCHEMISTRY (1981)
MCGEER, P.L., ENZYMES ASSOCIATED WITH METABOLISM OF CATECHOLAMINES, ACETYLCHOLINE AND GABA IN HUMAN CONTROLS AND PATIENTS WITH PARKINSONS-DISEASE AND HUNTINGTONS-CHOREA, JOURNAL OF NEUROCHEMISTRY 26: 65 (1976). (10.1111/j.1471-4159.1976.tb04437.x) / JOURNAL OF NEUROCHEMISTRY (1976)
MESULAM, M.M., CENTRAL CHOLINERGIC PATHWAYS IN THE RAT - AN OVERVIEW BASED ON AN ALTERNATIVE NOMENCLATURE (CH1-CH6), NEUROSCIENCE 10: 1185 (1983). (10.1016/0306-4522(83)90108-2) / NEUROSCIENCE (1983)
MESULAM, M.M., ATLAS OF CHOLINERGIC NEURONS IN THE FOREBRAIN AND UPPER BRAIN-STEM OF THE MACAQUE BASED ON MONOCLONAL CHOLINE-ACETYLTRANSFERASE IMMUNOHISTOCHEMISTRY AND ACETYLCHOLINESTERASE HISTOCHEMISTRY, NEUROSCIENCE 12: 669 (1984). (10.1016/0306-4522(84)90163-5) / NEUROSCIENCE (1984)
MOBLEY, W.C., CHARACTERIZATION AND ISOLATION OF PROTEOLYTICALLY MODIFIED NERVE GROWTH-FACTOR, BIOCHEMISTRY 15: 5543 (1976). (10.1021/bi00670a019) / BIOCHEMISTRY (1976)
MOBLEY, W.C., NERVE GROWTH-FACTOR .1., NEW ENGLAND JOURNAL OF MEDICINE 297: 1096 (1977). (10.1056/NEJM197711172972005) / NEW ENGLAND JOURNAL OF MEDICINE (1977)
MOBLEY, W.C., NERVE GROWTH-FACTOR .2., NEW ENGLAND JOURNAL OF MEDICINE 297: 1149 (1977). (10.1056/NEJM197711242972105) / NEW ENGLAND JOURNAL OF MEDICINE (1977)
MOBLEY, W.C., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 10: 367 (1984). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1984)
PRICE, D.L., NEUROSCIENCE COMMENTARIES 1: 84 (1982). / NEUROSCIENCE COMMENTARIES (1982)
PULLMAN S COMMUNICATION.
RICHARDSON, R, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 10: 128 (1984). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1984)
RIOPELLE, R.J., SOME ASPECTS OF PORPHYRIN NEUROTOXICITY INVITRO, CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 60: 707 (1982). (10.1139/y82-096) / CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (1982)
SCHWAB, M.E., NERVE GROWTH-FACTOR (NGF) IN THE RAT CNS - ABSENCE OF SPECIFIC RETROGRADE AXONAL-TRANSPORT AND TYROSINE-HYDROXYLASE INDUCTION IN LOCUS COERULEUS AND SUBSTANTIA NIGRA, BRAIN RESEARCH 168: 473 (1979). (10.1016/0006-8993(79)90303-2) / BRAIN RESEARCH (1979)
SEILER, M, SPECIFIC RETROGRADE TRANSPORT OF NERVE GROWTH-FACTOR (NGF) FROM NEOCORTEX TO NUCLEUS BASALIS IN THE RAT, BRAIN RESEARCH 300: 33 (1984). (10.1016/0006-8993(84)91338-6) / BRAIN RESEARCH (1984)
SHELTON, D.L., EXPRESSION OF THE BETA-NERVE GROWTH-FACTOR GENE CORRELATES WITH THE DENSITY OF SYMPATHETIC INNERVATION IN EFFECTOR ORGANS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 7951 (1984). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1984)
SPOKES, EGS, NEUROCHEMICAL ALTERATIONS IN HUNTINGTON CHOREA - A STUDY OF POSTMORTEM BRAIN-TISSUE, BRAIN 103: 179 (1980). (10.1093/brain/103.1.179) / BRAIN (1980)
STAHL, W.L., BIOCHEMICAL ABNORMALITIES IN HUNTINGTONS-CHOREA BRAINS, NEUROLOGY 24: 813 (1974). (10.1212/WNL.24.9.813) / NEUROLOGY (1974)
10.1152/physrev.1980.60.4.1284
VARON, S, NEURONOTROPHIC AND NEURITE-PROMOTING FACTORS AND THEIR CLINICAL POTENTIALS, DEVELOPMENTAL NEUROSCIENCE 6: 73 (1984). / DEVELOPMENTAL NEUROSCIENCE (1984)
ZIMMERMANN, A, SEROLOGICAL ASSAY FOR THE DETECTION OF CELL-SURFACE RECEPTORS OF NERVE GROWTH-FACTOR, JOURNAL OF SUPRAMOLECULAR STRUCTURE 9: 351 (1978). (10.1002/jss.400090306) / JOURNAL OF SUPRAMOLECULAR STRUCTURE (1978)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:25 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 12, 2024, 7:39 p.m.)
Issued	40 years, 1 month ago (July 19, 1985)
Published	40 years, 1 month ago (July 19, 1985)
Published Print	40 years, 1 month ago (July 19, 1985)

Funders 0

None

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