Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies
10.1126/science.286.5447.2156
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Natural antibodies are often dismissed from immunological analysis as “background,” but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or with Listeria monocytogenes , viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were 10 to 100 times lower than in antibody-competent mice. Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen-trapping in secondary lymphoid organs.

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Ochsenbein, A. F., Fehr, T., Lutz, C., Suter, M., Brombacher, F., Hengartner, H., & Zinkernagel, R. M. (1999). Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies. Science, 286(5447), 2156–2159.

Authors 7
  1. Adrian F. Ochsenbein (first)
  2. Thomas Fehr (additional)
  3. Claudia Lutz (additional)
  4. Mark Suter (additional)
  5. Frank Brombacher (additional)
  6. Hans Hengartner (additional)
  7. Rolf M. Zinkernagel (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:37 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 5:31 a.m.)
Indexed 1 week ago (Aug. 21, 2025, 1:46 p.m.)
Issued 25 years, 8 months ago (Dec. 10, 1999)
Published 25 years, 8 months ago (Dec. 10, 1999)
Published Print 25 years, 8 months ago (Dec. 10, 1999)
Funders 0

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@article{Ochsenbein_1999, title={Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies}, volume={286}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.286.5447.2156}, DOI={10.1126/science.286.5447.2156}, number={5447}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ochsenbein, Adrian F. and Fehr, Thomas and Lutz, Claudia and Suter, Mark and Brombacher, Frank and Hengartner, Hans and Zinkernagel, Rolf M.}, year={1999}, month=dec, pages={2156–2159} }