Crossref
journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract
The Drosophila Polycomb and trithorax group proteins act through chromosomal elements such as Fab-7 to maintain repressed or active gene expression, respectively. A Fab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription. Here, histone H4 hyperacetylation was found to be associated with Fab-7 after activation, suggesting that H4 hyperacetylation may be a heritable epigenetic tag of the activated element. Activated Fab-7 enables transcription of a gene even after withdrawal of the primary transcription factor. This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators.
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10.1016/S0092-8674(00)80740-0- G. Cavalli and R. Paro data not shown.
- We thank F. Sauer M. Méchali L. Ringrose and I. Chen for comments and critical reading of the manuscript; C. Grimaud for support in genetic analyses of PcG and trxG mutant strains; H. Ehret for technical support; and Y. Cully for photographic work. G.C. was supported by a European Molecular Biology Organization long-term fellowship. The work of G.C. is funded by grants from the Association pour la Recherche sur le Cancer and by the Fondation pour la Recherche Médicale. The work of R.P. is funded by grants from the Deutsche Forschungsgemeinschaft and the Human Frontier Science Program and by the Fond der Chemischen Industrie.
Dates
| Type | When |
|---|---|
| Created | 23 years, 1 month ago (July 27, 2002, 5:49 a.m.) |
| Deposited | 1 year, 7 months ago (Jan. 13, 2024, 5:34 a.m.) |
| Indexed | 3 weeks, 3 days ago (Aug. 6, 2025, 9:37 a.m.) |
| Issued | 25 years, 10 months ago (Oct. 29, 1999) |
| Published | 25 years, 10 months ago (Oct. 29, 1999) |
| Published Print | 25 years, 10 months ago (Oct. 29, 1999) |
@article{Cavalli_1999, title={Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator}, volume={286}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.286.5441.955}, DOI={10.1126/science.286.5441.955}, number={5441}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cavalli, Giacomo and Paro, Renato}, year={1999}, month=oct, pages={955–958} }