Gene Expression Profile of Aging and Its Retardation by Caloric Restriction
10.1126/science.285.5432.1390
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.

Bibliography

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999). Gene Expression Profile of Aging and Its Retardation by Caloric Restriction. Science, 285(5432), 1390–1393.

Authors 4
  1. Cheol-Koo Lee (first)
  2. Roger G. Klopp (additional)
  3. Richard Weindruch (additional)
  4. Tomas A. Prolla (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:42 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 3:54 a.m.)
Indexed 4 weeks, 2 days ago (Aug. 2, 2025, 12:41 a.m.)
Issued 26 years ago (Aug. 27, 1999)
Published 26 years ago (Aug. 27, 1999)
Published Print 26 years ago (Aug. 27, 1999)
Funders 0

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@article{Lee_1999, title={Gene Expression Profile of Aging and Its Retardation by Caloric Restriction}, volume={285}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.285.5432.1390}, DOI={10.1126/science.285.5432.1390}, number={5432}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Lee, Cheol-Koo and Klopp, Roger G. and Weindruch, Richard and Prolla, Tomas A.}, year={1999}, month=aug, pages={1390–1393} }