DOI: 10.1126/science.285.5430.1028. Integrin Signaling

Integrin Signaling

10.1126/science.285.5430.1028

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it. These signals regulate the activities of cytoplasmic kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate.

Bibliography

Giancotti, F. G., & Ruoslahti, E. (1999). Integrin Signaling. Science, 285(5430), 1028â1033.

Authors 2

Filippo G. Giancotti (first)
Erkki Ruoslahti (additional)

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We thank K. Vuori for comments. Research in the authors' laboratories is funded by the NIH. F.G.G. is an established investigator of the American Heart Association.

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:37 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 3:57 a.m.)
Indexed	1 day, 19 hours ago (Aug. 31, 2025, 6:06 a.m.)
Issued	26 years ago (Aug. 13, 1999)
Published	26 years ago (Aug. 13, 1999)
Published Print	26 years ago (Aug. 13, 1999)

Funders 0

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BibTeX

@article{Giancotti_1999, title={Integrin Signaling}, volume={285}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.285.5430.1028}, DOI={10.1126/science.285.5430.1028}, number={5430}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Giancotti, Filippo G. and Ruoslahti, Erkki}, year={1999}, month=aug, pages={1028–1033} }

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  "abstract": "<jats:p>Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it. These signals regulate the activities of cytoplasmic kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate.</jats:p>",
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