Correlational Structure of Spontaneous Neuronal Activity in the Developing Lateral Geniculate Nucleus in Vivo
10.1126/science.285.5427.599
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The properties of spontaneous activity in the developing visual pathway beyond the retina are unknown. Multielectrode recordings in the lateral geniculate nucleus (LGN) of awake behaving ferrets, before eye opening, revealed patterns of spontaneous activity that reflect a reshaping of retinal drive within higher visual stages. Significant binocular correlations were present only when cortico-thalamic feedback was intact. In the absence of retinal drive, cortico-thalamic feedback was required to sustain correlated LGN bursting. Activity originating from the contralateral eye drove thalamic activity far more strongly than that originating from the ipsilateral eye. Thus, in vivo patterns of LGN spontaneous activity emerge from interactions between retina, thalamus, and cortex.

Bibliography

Weliky, M., & Katz, L. C. (1999). Correlational Structure of Spontaneous Neuronal Activity in the Developing Lateral Geniculate Nucleus in Vivo. Science, 285(5427), 599–604.

Authors 2
  1. Michael Weliky (first)
  2. Lawrence C. Katz (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:50 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 4:40 a.m.)
Indexed 1 month, 1 week ago (July 25, 2025, 6:47 a.m.)
Issued 26 years, 1 month ago (July 23, 1999)
Published 26 years, 1 month ago (July 23, 1999)
Published Print 26 years, 1 month ago (July 23, 1999)
Funders 0

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@article{Weliky_1999, title={Correlational Structure of Spontaneous Neuronal Activity in the Developing Lateral Geniculate Nucleus in Vivo}, volume={285}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.285.5427.599}, DOI={10.1126/science.285.5427.599}, number={5427}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Weliky, Michael and Katz, Lawrence C.}, year={1999}, month=jul, pages={599–604} }