DOI: 10.1126/science.2845577. Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission

Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission

10.1126/science.2845577

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Brief repetitive activation of excitatory synapses in the hippocampus leads to an increase in synaptic strength that lasts for many hours. This long-term potentiation (LTP) of synaptic transmission is the most compelling cellular model in the vertebrate brain for learning and memory. The critical role of postsynaptic calcium in triggering LTP has been directly examined using three types of experiment. First, nitr-5, a photolabile nitrobenzhydrol tetracarboxylate calcium chelator, which releases calcium in response to ultraviolet light, was used. Photolysis of nitr-5 injected into hippocampal CA1 pyramidal cells resulted in a large enhancement of synaptic transmission. Second, in agreement with previous results, buffering intracellular calcium at low concentrations blocked LTP. Third, depolarization of the postsynaptic membrane so that calcium entry is suppressed prevented LTP. Taken together, these results demonstrate that an increase in postsynaptic calcium is necessary to induce LTP and sufficient to potentiate synaptic transmission.

Bibliography

Malenka, R. C., Kauer, J. A., Zucker, R. S., & Nicoll, R. A. (1988). Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission. Science, 242(4875), 81â84.

Authors 4

Robert C. Malenka (first)
Julie A. Kauer (additional)
Robert S. Zucker (additional)
Roger A. Nicoll (additional)

References 40 Referenced 625

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 5:17 a.m.)
Indexed	4 hours, 27 minutes ago (Aug. 21, 2025, 12:27 p.m.)
Issued	36 years, 10 months ago (Oct. 7, 1988)
Published	36 years, 10 months ago (Oct. 7, 1988)
Published Print	36 years, 10 months ago (Oct. 7, 1988)

Funders 0

None

BibTeX

@article{Malenka_1988, title={Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission}, volume={242}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2845577}, DOI={10.1126/science.2845577}, number={4875}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Malenka, Robert C. and Kauer, Julie A. and Zucker, Robert S. and Nicoll, Roger A.}, year={1988}, month=oct, pages={81–84} }

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