Helicobacter pylori Virulence and Genetic Geography
10.1126/science.284.5418.1328
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori .

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Covacci, A., Telford, J. L., Giudice, G. D., Parsonnet, J., & Rappuoli, R. (1999). Helicobacter pylori Virulence and Genetic Geography. Science, 284(5418), 1328–1333.

Authors 5
  1. Antonello Covacci (first)
  2. John L. Telford (additional)
  3. Giuseppe Del Giudice (additional)
  4. Julie Parsonnet (additional)
  5. Rino Rappuoli (additional)
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Dates
Type When
Created 23 years ago (July 27, 2002, 5:37 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 4:28 a.m.)
Indexed 3 days ago (Aug. 23, 2025, 9:14 p.m.)
Issued 26 years, 3 months ago (May 21, 1999)
Published 26 years, 3 months ago (May 21, 1999)
Published Print 26 years, 3 months ago (May 21, 1999)
Funders 0

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@article{Covacci_1999, title={Helicobacter pylori Virulence and Genetic Geography}, volume={284}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.284.5418.1328}, DOI={10.1126/science.284.5418.1328}, number={5418}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Covacci, Antonello and Telford, John L. and Giudice, Giuseppe Del and Parsonnet, Julie and Rappuoli, Rino}, year={1999}, month=may, pages={1328–1333} }