Bone Marrow as a Potential Source of Hepatic Oval Cells
10.1126/science.284.5417.1168
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.

Bibliography

Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., & Goff, J. P. (1999). Bone Marrow as a Potential Source of Hepatic Oval Cells. Science, 284(5417), 1168–1170.

Authors 9
  1. B. E. Petersen (first)
  2. W. C. Bowen (additional)
  3. K. D. Patrene (additional)
  4. W. M. Mars (additional)
  5. A. K. Sullivan (additional)
  6. N. Murase (additional)
  7. S. S. Boggs (additional)
  8. J. S. Greenberger (additional)
  9. J. P. Goff (additional)
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  28. We thank L. Shab J. Kalfs and R. Dravian for help with the figures; B. Lombardi P. Lindroos D. Beer-Stolz and M. Molitor for review of the manuscript; S. Gupta for DPPIV − female F-344 rats; and R. Farris and D. Hixson for antibodies.
Dates
Type When
Created 23 years ago (July 27, 2002, 5:42 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 4:06 a.m.)
Indexed 4 days, 19 hours ago (Aug. 21, 2025, 12:41 p.m.)
Issued 26 years, 3 months ago (May 14, 1999)
Published 26 years, 3 months ago (May 14, 1999)
Published Print 26 years, 3 months ago (May 14, 1999)
Funders 0

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@article{Petersen_1999, title={Bone Marrow as a Potential Source of Hepatic Oval Cells}, volume={284}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.284.5417.1168}, DOI={10.1126/science.284.5417.1168}, number={5417}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Petersen, B. E. and Bowen, W. C. and Patrene, K. D. and Mars, W. M. and Sullivan, A. K. and Murase, N. and Boggs, S. S. and Greenberger, J. S. and Goff, J. P.}, year={1999}, month=may, pages={1168–1170} }