Chemokine Up-Regulation and Activated T Cell Attraction by Maturing Dendritic Cells
10.1126/science.284.5415.819
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Langerhans' cells migrating from contact-sensitized skin were found to up-regulate expression of macrophage-derived chemokine (MDC) during maturation into lymph node dendritic cells (DCs). Naı̈ve T cells did not migrate toward MDC, but antigen-specific T cells rapidly acquired MDC responsiveness in vivo after a subcutaneous injection of antigen. In chemotaxis assays, maturing DCs attracted activated T cells more strongly than naı̈ve T cells. These studies identified chemokine up-regulation as part of the Langerhans' cell maturation program to immunogenic T cell–zone DC. Preferential recruitment of activated T cells may be a mechanism used by maturing DCs to promote encounters with antigen-specific T cells.

Bibliography

Tang, H. L., & Cyster, J. G. (1999). Chemokine Up-Regulation and Activated T Cell Attraction by Maturing Dendritic Cells. Science, 284(5415), 819–822.

Authors 2
  1. H. Lucy Tang (first)
  2. Jason G. Cyster (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:37 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 4:19 a.m.)
Indexed 1 month, 1 week ago (July 24, 2025, 8:05 a.m.)
Issued 26 years, 4 months ago (April 30, 1999)
Published 26 years, 4 months ago (April 30, 1999)
Published Print 26 years, 4 months ago (April 30, 1999)
Funders 0

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@article{Tang_1999, title={Chemokine Up-Regulation and Activated T Cell Attraction by Maturing Dendritic Cells}, volume={284}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.284.5415.819}, DOI={10.1126/science.284.5415.819}, number={5415}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Tang, H. Lucy and Cyster, Jason G.}, year={1999}, month=apr, pages={819–822} }