Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition
10.1126/science.284.5411.156
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The ability of p53 to promote apoptosis in response to mitogenic oncogenes appears to be critical for its tumor suppressor function. Caspase-9 and its cofactor Apaf-1 were found to be essential downstream components of p53 in Myc-induced apoptosis. Like p53 null cells, mouse embryo fibroblast cells deficient in Apaf-1 and caspase-9, and expressing c- Myc , were resistant to apoptotic stimuli that mimic conditions in developing tumors. Inactivation of Apaf-1 or caspase-9 substituted for p53 loss in promoting the oncogenic transformation of Myc -expressing cells. These results imply a role for Apaf-1 and caspase-9 in controlling tumor development.

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Soengas, M. S., Alarcón, R. M., Yoshida, H., J., A., Giaccia, Hakem, R., Mak, T. W., & Lowe, S. W. (1999). Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition. Science, 284(5411), 156–159.

Authors 8
  1. M. S. Soengas (first)
  2. R. M. Alarcón (additional)
  3. H. Yoshida (additional)
  4. A. J. (additional)
  5. Giaccia (additional)
  6. R. Hakem (additional)
  7. T. W. Mak (additional)
  8. S. W. Lowe (additional)
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Dates
Type When
Created 23 years ago (July 27, 2002, 5:48 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 12:26 a.m.)
Indexed 3 weeks, 2 days ago (Aug. 3, 2025, 12:35 a.m.)
Issued 26 years, 4 months ago (April 2, 1999)
Published 26 years, 4 months ago (April 2, 1999)
Published Print 26 years, 4 months ago (April 2, 1999)
Funders 0

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@article{Soengas_1999, title={Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition}, volume={284}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.284.5411.156}, DOI={10.1126/science.284.5411.156}, number={5411}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Soengas, M. S. and Alarcón, R. M. and Yoshida, H. and J., A. and Giaccia and Hakem, R. and Mak, T. W. and Lowe, S. W.}, year={1999}, month=apr, pages={156–159} }