DOI: 10.1126/science.2838904. Brownian Dynamics of Cytochrome c and Cytochrome c Peroxidase Association

Brownian Dynamics of Cytochrome c and Cytochrome c Peroxidase Association

10.1126/science.2838904

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Brownian dynamics computer simulations of the diffusional association of electron transport proteins cytochrome c (cyt c) and cytochrome c peroxidase (cyt c per) were performed. A highly detailed and realistic model of the protein structures and their electrostatic interactions was used that was based on an atomic-level spatial description. Several structural features played a role in enhancing and optimizing the electron transfer efficiency of this reaction. Favorable electrostatic interactions facilitated long-lived nonspecific encounters between the proteins that allowed the severe orientational criteria for reaction to be overcome by rotational diffusion during encounters. Thus a "reduction-in-dimensionality" effect operated. The proteins achieved plausible electron transfer orientations in a multitude of electrostatically stable encounter complexes, rather than in a single dominant complex.

Bibliography

Northrup, S. H., Boles, J. O., & Reynolds, J. C. L. (1988). Brownian Dynamics of Cytochrome c and Cytochrome c Peroxidase Association. Science, 241(4861), 67â70.

Authors 3

Scott H. Northrup (first)
Jeffrey O. Boles (additional)
John C. L. Reynolds (additional)

References 31 Referenced 234

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 10:48 p.m.)
Indexed	1 month, 3 weeks ago (June 27, 2025, 6:52 a.m.)
Issued	37 years, 1 month ago (July 1, 1988)
Published	37 years, 1 month ago (July 1, 1988)
Published Print	37 years, 1 month ago (July 1, 1988)

Funders 0

None

BibTeX

@article{Northrup_1988, title={Brownian Dynamics of Cytochrome c and Cytochrome c Peroxidase Association}, volume={241}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2838904}, DOI={10.1126/science.2838904}, number={4861}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Northrup, Scott H. and Boles, Jeffrey O. and Reynolds, John C. L.}, year={1988}, month=jul, pages={67–70} }

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