CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells
10.1126/science.283.5399.225
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)–restricted recognition of peptide fragments by conventional CD4 + helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)- anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4–producing CD4 + , natural killer cell antigen 1.1 [(NK1.1) + ] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.

Bibliography

Schofield, L., McConville, M. J., Hansen, D., Campbell, A. S., Fraser-Reid, B., Grusby, M. J., & Tachado, S. D. (1999). CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells. Science, 283(5399), 225–229.

Authors 7
  1. Louis Schofield (first)
  2. Malcolm J. McConville (additional)
  3. Diana Hansen (additional)
  4. A. Stewart Campbell (additional)
  5. Bert Fraser-Reid (additional)
  6. Michael J. Grusby (additional)
  7. Souvenir D. Tachado (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:45 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 12:05 a.m.)
Indexed 1 month, 4 weeks ago (July 7, 2025, 10:28 a.m.)
Issued 26 years, 7 months ago (Jan. 8, 1999)
Published 26 years, 7 months ago (Jan. 8, 1999)
Published Print 26 years, 7 months ago (Jan. 8, 1999)
Funders 0

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@article{Schofield_1999, title={CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells}, volume={283}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.283.5399.225}, DOI={10.1126/science.283.5399.225}, number={5399}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schofield, Louis and McConville, Malcolm J. and Hansen, Diana and Campbell, A. Stewart and Fraser-Reid, Bert and Grusby, Michael J. and Tachado, Souvenir D.}, year={1999}, month=jan, pages={225–229} }