A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene
10.1126/science.2825356
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Growth factors and their receptors are involved in the regulation of cell proliferation and also play a key role in oncogenesis. In this study, a novel putative kinase receptor gene, termed eph , has been identified and characterized by molecular cloning. Its primary structure is similar to that of tyrosine kinase receptors thus far cloned and includes a cysteine-rich region in the extracellular domain. However, other features of the sequence distinguish the eph gene product from known receptors with tyrosine kinase activity. Thus the eph protein may define a new class of these molecules. The eph gene is overexpressed in several human carcinomas, suggesting that this gene may be involved in the neoplastic process of some tumors.

Bibliography

Hirai, H., Maru, Y., Hagiwara, K., Nishida, J., & Takaku, F. (1987). A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene. Science, 238(4834), 1717–1720.

Authors 5
  1. Hisamaru Hirai (first)
  2. Yoshiro Maru (additional)
  3. Koichi Hagiwara (additional)
  4. Junji Nishida (additional)
  5. Fumimaro Takaku (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 11:10 p.m.)
Indexed 30 minutes ago (Aug. 31, 2025, 1:16 a.m.)
Issued 37 years, 8 months ago (Dec. 18, 1987)
Published 37 years, 8 months ago (Dec. 18, 1987)
Published Print 37 years, 8 months ago (Dec. 18, 1987)
Funders 0

None

@article{Hirai_1987, title={A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene}, volume={238}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2825356}, DOI={10.1126/science.2825356}, number={4834}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hirai, Hisamaru and Maru, Yoshiro and Hagiwara, Koichi and Nishida, Junji and Takaku, Fumimaro}, year={1987}, month=dec, pages={1717–1720} }