Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx
10.1126/science.281.5384.1860
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The Fas death receptor can activate the Jun NH 2 -terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors.

Bibliography

Chang, H. Y., Nishitoh, H., Yang, X., Ichijo, H., & Baltimore, D. (1998). Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx. Science, 281(5384), 1860–1863.

Authors 5
  1. Howard Y. Chang (first)
  2. Hideki Nishitoh (additional)
  3. Xiaolu Yang (additional)
  4. Hidenori Ichijo (additional)
  5. David Baltimore (additional)
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  35. We are grateful to P. Svec for technical support. We thank S. Nagata K. Matsumoto J. Wang M. J. Lenardo D. V. Goeddel M. Goeddert and Z. Yao for reagents and A. Hoffmann for valuable advice and critical review of the manuscript. H.I. thanks K. Miyazono for valuable discussion. H.Y.C. is supported by the Medical Scientist Training Program at Harvard Medical School. H.I. is supported by Grants-in-Aid for scientific research from the Ministry of Education Science and Culture of Japan. X.Y. is a fellow of the Leukemia Society of America. Supported by NIH grant CA51462.
Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:37 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 10:27 p.m.)
Indexed 2 weeks, 3 days ago (Aug. 12, 2025, 5:53 p.m.)
Issued 26 years, 11 months ago (Sept. 18, 1998)
Published 26 years, 11 months ago (Sept. 18, 1998)
Published Print 26 years, 11 months ago (Sept. 18, 1998)
Funders 0

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@article{Chang_1998, title={Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx}, volume={281}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.281.5384.1860}, DOI={10.1126/science.281.5384.1860}, number={5384}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Chang, Howard Y. and Nishitoh, Hideki and Yang, Xiaolu and Ichijo, Hidenori and Baltimore, David}, year={1998}, month=sep, pages={1860–1863} }