A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation
10.1126/science.281.5383.1671
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The c-Jun NH 2 -terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.

Bibliography

Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J. (1998). A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation. Science, 281(5383), 1671–1674.

Authors 5
  1. Alan J. Whitmarsh (first)
  2. Julie Cavanagh (additional)
  3. Cathy Tournier (additional)
  4. Jun Yasuda (additional)
  5. Roger J. Davis (additional)
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  34. We thank our colleagues for providing essential reagents T. Barrett for DNA sequence analysis and K. Gemme for secretarial assistance. Supported by a grant from the National Cancer Institute. R.J.D. is an Investigator of the Howard Hughes Medical Institute.
Dates
Type When
Created 23 years ago (July 27, 2002, 5:43 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 10:28 p.m.)
Indexed 1 month, 1 week ago (July 14, 2025, 11:40 p.m.)
Issued 26 years, 11 months ago (Sept. 11, 1998)
Published 26 years, 11 months ago (Sept. 11, 1998)
Published Print 26 years, 11 months ago (Sept. 11, 1998)
Funders 0

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@article{Whitmarsh_1998, title={A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation}, volume={281}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.281.5383.1671}, DOI={10.1126/science.281.5383.1671}, number={5383}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Whitmarsh, Alan J. and Cavanagh, Julie and Tournier, Cathy and Yasuda, Jun and Davis, Roger J.}, year={1998}, month=sep, pages={1671–1674} }