An Integrated Model of the Transcription Complex in Elongation, Termination, and Editing
10.1126/science.281.5377.660
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Recent findings now allow the development of an integrated model of the thermodynamic, kinetic, and structural properties of the transcription complex in the elongation, termination, and editing phases of transcript formation. This model provides an operational framework for placing known facts and can be extended and modified to incorporate new advances. The most complete information about transcriptional mechanisms and their control continues to come from the Escherichia coli system, upon which most of the explicit descriptions provided here are based. The transcriptional machinery of higher organisms, despite its greater inherent complexity, appears to use many of the same general principles. Thus, the lessons of E. coli continue to be relevant.

Bibliography

von Hippel, P. H. (1998). An Integrated Model of the Transcription Complex in Elongation, Termination, and Editing. Science, 281(5377), 660–665.

Authors 1
  1. Peter H. von Hippel (first)
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  79. I thank my laboratory colleagues whose experimental and theoretical work has led to many of the ideas developed here as well as many colleagues at the University of Oregon and elsewhere for stimulating discussions. References included in this article can only “scratch the surface” in acknowledging the work of colleagues in other laboratories and of those who came before. The preparation of this article was supported in part by U.S. Public Health Service research grants GM-15792 and GM-29158. The author is an American Cancer Society Research Professor of Chemistry.
Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:49 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 10:03 p.m.)
Indexed 1 month, 2 weeks ago (July 11, 2025, 6:40 a.m.)
Issued 27 years ago (July 31, 1998)
Published 27 years ago (July 31, 1998)
Published Print 27 years ago (July 31, 1998)
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@article{von_Hippel_1998, title={An Integrated Model of the Transcription Complex in Elongation, Termination, and Editing}, volume={281}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.281.5377.660}, DOI={10.1126/science.281.5377.660}, number={5377}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={von Hippel, Peter H.}, year={1998}, month=jul, pages={660–665} }