A Conserved HIV gp120 Glycoprotein Structure Involved in Chemokine Receptor Binding
10.1126/science.280.5371.1949
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The entry of primate immunodeficiency viruses into target cells depends on a sequential interaction of the gp120 envelope glycoprotein with the cellular receptors, CD4 and members of the chemokine receptor family. The gp120 third variable (V3) loop has been implicated in chemokine receptor binding, but the use of the CCR5 chemokine receptor by diverse primate immunodeficiency viruses suggests the involvement of an additional, conserved gp120 element. Through the use of gp120 mutants, a highly conserved gp120 structure was shown to be critical for CCR5 binding. This structure is located adjacent to the V3 loop and contains neutralization epitopes induced by CD4 binding. This conserved element may be a useful target for pharmacologic or prophylactic intervention in human immunodeficiency virus (HIV) infections.

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Rizzuto, C. D., Wyatt, R., Hernández-Ramos, N., Sun, Y., Kwong, P. D., Hendrickson, W. A., & Sodroski, J. (1998). A Conserved HIV gp120 Glycoprotein Structure Involved in Chemokine Receptor Binding. Science, 280(5371), 1949–1953.

Authors 7
  1. Carlo D. Rizzuto (first)
  2. Richard Wyatt (additional)
  3. Nivia Hernández-Ramos (additional)
  4. Ying Sun (additional)
  5. Peter D. Kwong (additional)
  6. Wayne A. Hendrickson (additional)
  7. Joseph Sodroski (additional)
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Dates
Type When
Created 23 years ago (July 27, 2002, 5:37 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 12:08 a.m.)
Indexed 1 week, 5 days ago (Aug. 12, 2025, 5:45 p.m.)
Issued 27 years, 2 months ago (June 19, 1998)
Published 27 years, 2 months ago (June 19, 1998)
Published Print 27 years, 2 months ago (June 19, 1998)
Funders 0

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@article{Rizzuto_1998, title={A Conserved HIV gp120 Glycoprotein Structure Involved in Chemokine Receptor Binding}, volume={280}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.280.5371.1949}, DOI={10.1126/science.280.5371.1949}, number={5371}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rizzuto, Carlo D. and Wyatt, Richard and Hernández-Ramos, Nivia and Sun, Ying and Kwong, Peter D. and Hendrickson, Wayne A. and Sodroski, Joseph}, year={1998}, month=jun, pages={1949–1953} }