The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens
10.1126/science.280.5371.1884
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The human immunodeficiency virus–type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1 envelope glycoproteins and, ultimately, aid in HIV-1 vaccine development.

Bibliography

Wyatt, R., & Sodroski, J. (1998). The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens. Science, 280(5371), 1884–1888.

Authors 2
  1. Richard Wyatt (first)
  2. Joseph Sodroski (additional)
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Dates
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Created 23 years ago (July 27, 2002, 5:50 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 12:12 a.m.)
Indexed 2 hours, 57 minutes ago (Aug. 21, 2025, 1:56 p.m.)
Issued 27 years, 2 months ago (June 19, 1998)
Published 27 years, 2 months ago (June 19, 1998)
Published Print 27 years, 2 months ago (June 19, 1998)
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@article{Wyatt_1998, title={The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens}, volume={280}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.280.5371.1884}, DOI={10.1126/science.280.5371.1884}, number={5371}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Wyatt, Richard and Sodroski, Joseph}, year={1998}, month=jun, pages={1884–1888} }