DOI: 10.1126/science.2799385. Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1 [Penn]

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

10.1126/science.2799385

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Interleukin-1 (IL-1) is a major regulator of inflammation and immunity. IL-1 induces T lymphocyte growth by acting as a second signal (together with antigen) in enhancing the production of interleukin-2 (IL-2). An IL-1-responsive element in the promoter region of the human IL-2 gene was similar to the binding site for the transcription factor AP-1. IL-1 enhanced expression of c- jun messenger RNA, whereas the antigenic signal enhanced messenger RNA expression of c- fos . Thus, the two components of the AP-1 factor are independently regulated and the AP-1 factor may serve as a nuclear mediator for the many actions of IL-1 on cells.

Bibliography

Muegge, K., Williams, T. M., Kant, J., Karin, M., Chiu, R., Schmidt, A., Siebenlist, U., Young, H. A., & Durum, S. K. (1989). Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1. Science, 246(4927), 249â251.

Authors 9

Kathrin Muegge (first)
Thomas M. Williams (additional)
Jeffrey Kant (additional)
Michael Karin (additional)
Robert Chiu (additional)
Albrecht Schmidt (additional)
Ulrich Siebenlist (additional)
Howard A. Young (additional)
Scott K. Durum (additional)

References 31 Referenced 195

ABRAHAM, R.T., TRANSMEMBRANE SIGNALING DURING INTERLEUKIN 1-DEPENDENT T-CELL ACTIVATION - INTERACTIONS OF SIGNAL 1-TYPE AND SIGNAL 2-TYPE MEDIATORS WITH THE PHOSPHOINOSITIDE-DEPENDENT SIGNAL TRANSDUCTION MECHANISM, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 2719 (1987). (10.1016/S0021-9258(18)61566-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1987)
10.1016/0092-8674(87)90611-8
10.1016/0092-8674(88)90143-2
ANGEL, P, ONCOGENE JUN ENCODES A SEQUENCE-SPECIFIC TRANS-ACTIVATOR SIMILAR TO AP-1, NATURE 332: 166 (1988). (10.1038/332166a0) / NATURE (1988)
ARYA, S.K., TRANSCRIPTIONAL MODULATION OF HUMAN T-CELL GROWTH-FACTOR GENE BY PHORBOL ESTER AND INTERLEUKIN-1, BIOCHEMISTRY 23: 6685 (1984). (10.1021/bi00321a062) / BIOCHEMISTRY (1984)
10.1126/science.2825349
BRENNER, D.A., PROLONGED ACTIVATION OF JUN AND COLLAGENASE GENES BY TUMOR NECROSIS FACTOR-ALPHA, NATURE 337: 661 (1989). (10.1038/337661a0) / NATURE (1989)
10.1021/bi00591a005
10.1126/science.2783497
DEWET, J.R., FIREFLY LUCIFERASE GENE - STRUCTURE AND EXPRESSION IN MAMMALIAN-CELLS, MOLECULAR AND CELLULAR BIOLOGY 7: 725 (1987). / MOLECULAR AND CELLULAR BIOLOGY (1987)
DOWER, S.K., DETECTION AND CHARACTERIZATION OF HIGH-AFFINITY PLASMA-MEMBRANE RECEPTORS FOR HUMAN INTERLEUKIN-1, JOURNAL OF EXPERIMENTAL MEDICINE 162: 501 (1985). (10.1084/jem.162.2.501) / JOURNAL OF EXPERIMENTAL MEDICINE (1985)
DURAND, D.B., CHARACTERIZATION OF ANTIGEN RECEPTOR RESPONSE ELEMENTS WITHIN THE INTERLEUKIN-2 ENHANCER, MOLECULAR AND CELLULAR BIOLOGY 8: 1715 (1988). / MOLECULAR AND CELLULAR BIOLOGY (1988)
10.1093/nar/9.23.6505
GILLIS, S, T-CELL LYMPHOMA MODEL FOR THE ANALYSIS OF INTERLEUKIN 1-MEDIATED T-CELL ACTIVATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 1133 (1981). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1981)
GORMAN, C.M., RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS, MOLECULAR AND CELLULAR BIOLOGY 2: 1044 (1982). / MOLECULAR AND CELLULAR BIOLOGY (1982)
GORMAN, C.M., THE ROUS-SARCOMA VIRUS LONG TERMINAL REPEAT IS A STRONG PROMOTER WHEN INTRODUCED INTO A VARIETY OF EUKARYOTIC CELLS BY DNA-MEDIATED TRANSFECTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 6777 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)
HAGIWARA, H, INTERLEUKIN-1 MODULATES MESSENGER-RNA LEVELS OF LYMPHOKINES AND OF OTHER MOLECULES ASSOCIATED WITH T-CELL ACTIVATION IN THE T-CELL LYMPHOMA LBRM33-1A5, JOURNAL OF IMMUNOLOGY 138: 2514 (1987). (10.4049/jimmunol.138.8.2514) / JOURNAL OF IMMUNOLOGY (1987)
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MCNALLY, M.A., OPTIMIZING ELECTROPORATION PARAMETERS FOR A VARIETY OF HUMAN HEMATOPOIETIC-CELL LINES, BIOTECHNIQUES 6: 882 (1988). / BIOTECHNIQUES (1988)
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SHAPIRO, D.J., A HIGH-EFFICIENCY HELA-CELL NUCLEAR TRANSCRIPTION EXTRACT, DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 7: 47 (1988). / DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY (1988)
10.1126/science.2969618
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WILLIAMS, T.M., 2 REGIONS WITHIN THE HUMAN IL-2 GENE PROMOTER ARE IMPORTANT FOR INDUCIBLE IL-2 EXPRESSION, JOURNAL OF IMMUNOLOGY 141: 662 (1988). (10.4049/jimmunol.141.2.662) / JOURNAL OF IMMUNOLOGY (1988)
ZIFF, E, NATURE 336: 646 (1988). (10.1038/336646a0) / NATURE (1988)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 10:27 p.m.)
Indexed	1 month ago (Aug. 2, 2025, 12:22 a.m.)
Issued	35 years, 10 months ago (Oct. 13, 1989)
Published	35 years, 10 months ago (Oct. 13, 1989)
Published Print	35 years, 10 months ago (Oct. 13, 1989)

Funders 0

None

BibTeX

@article{Muegge_1989, title={Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1}, volume={246}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2799385}, DOI={10.1126/science.2799385}, number={4927}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Muegge, Kathrin and Williams, Thomas M. and Kant, Jeffrey and Karin, Michael and Chiu, Robert and Schmidt, Albrecht and Siebenlist, Ulrich and Young, Howard A. and Durum, Scott K.}, year={1989}, month=oct, pages={249–251} }

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