Target-Specific Expression of Presynaptic Mossy Fiber Plasticity
10.1126/science.279.5355.1368
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Mossy fiber synaptic transmission at hippocampal CA3 pyramidal cells and interneurons was compared in rat brain slices to determine whether mossy terminals are functionally equivalent. Tetanic stimulation of mossy fibers induced long-term potentiation in pyramidal neurons but was either without effect or it induced depression at synapses onto interneurons. Unlike transmission onto pyramidal neurons, transmission onto interneurons was not potentiated after adenosine 3′,5′-monophosphate (cAMP) activation. Furthermore, metabotropic glutamate receptor depression of transmission onto interneurons did not involve cAMP-dependent pathways. Thus, synaptic terminals arising from a common afferent pathway do not function as a single compartment but are specialized, depending on their postsynaptic target.

Bibliography

Maccaferri, G., Tóth, K., & McBain, C. J. (1998). Target-Specific Expression of Presynaptic Mossy Fiber Plasticity. Science, 279(5355), 1368–1371.

Authors 3
  1. Gianmaria Maccaferri (first)
  2. Katalin Tóth (additional)
  3. Chris J. McBain (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:42 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 12:56 a.m.)
Indexed 1 month, 3 weeks ago (July 8, 2025, 12:08 a.m.)
Issued 27 years, 6 months ago (Feb. 27, 1998)
Published 27 years, 6 months ago (Feb. 27, 1998)
Published Print 27 years, 6 months ago (Feb. 27, 1998)
Funders 0

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@article{Maccaferri_1998, title={Target-Specific Expression of Presynaptic Mossy Fiber Plasticity}, volume={279}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.279.5355.1368}, DOI={10.1126/science.279.5355.1368}, number={5355}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Maccaferri, Gianmaria and Tóth, Katalin and McBain, Chris J.}, year={1998}, month=feb, pages={1368–1371} }