DOI: 10.1126/science.279.5352.873. Conjugative Transfer by the Virulence System of <i>Legionella pneumophila</i>

Conjugative Transfer by the Virulence System of Legionella pneumophila

10.1126/science.279.5352.873

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Legionella pneumophila , the causative agent of Legionnaires' pneumonia, replicates within alveolar macrophages by preventing phagosome-lysosome fusion. Here, a large number of mutants called dot (defective for organelle trafficking) that were unable to replicate intracellularly because of an inability of the bacteria to alter the endocytic pathway of macrophages were isolated. The dot virulence genes encoded a large putative membrane complex that functioned as a secretion system that was able to transfer plasmid DNA from one cell to another.

Bibliography

Vogel, Joseph. P., Andrews, H. L., Wong, S. K., & Isberg, R. R. (1998). Conjugative Transfer by the Virulence System of Legionella pneumophila. Science, 279(5352), 873â876.

Authors 4

Joseph. P. Vogel (first)
Helene L. Andrews (additional)
Swee Kee Wong (additional)
Ralph R. Isberg (additional)

References 42 Referenced 583

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:37 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 1 a.m.)
Indexed	1 week, 1 day ago (Aug. 21, 2025, 1:46 p.m.)
Issued	27 years, 6 months ago (Feb. 6, 1998)
Published	27 years, 6 months ago (Feb. 6, 1998)
Published Print	27 years, 6 months ago (Feb. 6, 1998)

Funders 0

None

BibTeX

@article{Vogel_1998, title={Conjugative Transfer by the Virulence System of Legionella pneumophila}, volume={279}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.279.5352.873}, DOI={10.1126/science.279.5352.873}, number={5352}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Vogel, Joseph. P. and Andrews, Helene L. and Wong, Swee Kee and Isberg, Ralph R.}, year={1998}, month=feb, pages={873–876} }

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