DOI: 10.1126/science.279.5350.509. Rho GTPases and the Actin Cytoskeleton

10.1126/science.279.5350.509

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.

Bibliography

Hall, A. (1998). Rho GTPases and the Actin Cytoskeleton. Science, 279(5350), 509â514.

Authors 1

Alan Hall (first)

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I would like to thank the Cancer Research Campaign (United Kingdom) The Wellcome Trust (United Kingdom) and the Medical Research Council (United Kingdom) for their financial support. I thank D. Mackay and C. Nobes for critical reading of this manuscript and C. Nobes D. Bray V. Braga and D. Mackay for help with the figures.

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:50 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 1:04 a.m.)
Indexed	8 hours, 12 minutes ago (Aug. 30, 2025, 12:37 p.m.)
Issued	27 years, 7 months ago (Jan. 23, 1998)
Published	27 years, 7 months ago (Jan. 23, 1998)
Published Print	27 years, 7 months ago (Jan. 23, 1998)

Funders 0

None

BibTeX

@article{Hall_1998, title={Rho GTPases and the Actin Cytoskeleton}, volume={279}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.279.5350.509}, DOI={10.1126/science.279.5350.509}, number={5350}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hall, Alan}, year={1998}, month=jan, pages={509–514} }

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