DOI: 10.1126/science.2786251. Autoimmune Target in Heymann Nephritis Is a Glycoprotein with Homology to the LDL Receptor

Autoimmune Target in Heymann Nephritis Is a Glycoprotein with Homology to the LDL Receptor

10.1126/science.2786251

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The pathogenesis of Heymann nephritis, a rat model of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal glycoprotein (GP330) on glomerular podocytes. Partial complementary DNAs coding for GP330 were isolated and sequenced. The deduced amino acid sequence from 4.3 kilobases of complementary DNA contains the sequences identical to two peptides derived from the isolated glycoprotein. The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family. Autoantibodies from the kidneys of rats with Heymann nephritis reacted with a nonglycosylated segment of GP330 that contains cysteine-rich 40-amino acid repeats, which are also features of the LDL receptor. GP330 is also similar in some regions to the mouse epidermal growth factor precursor.

Bibliography

Raychowdhury, R., Niles, J. L., McCluskey, R. T., & Smith, J. A. (1989). Autoimmune Target in Heymann Nephritis Is a Glycoprotein with Homology to the LDL Receptor. Science, 244(4909), 1163â1165.

Authors 4

Raktima Raychowdhury (first)
John L. Niles (additional)
Robert T. McCluskey (additional)
John A. Smith (additional)

References 31 Referenced 188

BAI, D.H., MOLECULAR-CLONING OF CDNA FOR ACETYL-COENZYME-A CARBOXYLASE, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 12395 (1986). (10.1016/S0021-9258(18)67253-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1986)
CAMUSSI, G, ANTIBODY-INDUCED REDISTRIBUTION OF HEYMANN ANTIGEN ON THE SURFACE OF CULTURED GLOMERULAR VISCERAL EPITHELIAL-CELLS - POSSIBLE ROLE IN THE PATHOGENESIS OF HEYMANN GLOMERULONEPHRITIS, JOURNAL OF IMMUNOLOGY 135: 2409 (1985). (10.4049/jimmunol.135.4.2409) / JOURNAL OF IMMUNOLOGY (1985)
CHATELET, F, ULTRASTRUCTURAL-LOCALIZATION BY MONOCLONAL-ANTIBODIES OF BRUSH-BORDER ANTIGENS EXPRESSED BY GLOMERULI .2. EXTRARENAL DISTRIBUTION, AMERICAN JOURNAL OF PATHOLOGY 122: 512 (1986). / AMERICAN JOURNAL OF PATHOLOGY (1986)
10.1093/nar/12.1Part1.387
DOXSEY, S, A LARGE MEMBRANE GLYCOPROTEIN (GP330) IS A RESIDENT OF COATED PITS OF SEVERAL ABSORBTIVE EPITHELIA, JOURNAL OF CELL BIOLOGY 97: A178 (1983). (10.1083/jcb.97.1.178) / JOURNAL OF CELL BIOLOGY (1983)
DRICKAMER, K, PRIMARY STRUCTURE OF THE RAT-LIVER ASIALOGLYCOPROTEIN RECEPTOR - STRUCTURAL EVIDENCE FOR MULTIPLE POLYPEPTIDE SPECIES, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 770 (1984). (10.1016/S0021-9258(17)43524-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1984)
GOLDSTEIN, J.L., RECEPTOR-MEDIATED ENDOCYTOSIS - CONCEPTS EMERGING FROM THE LDL RECEPTOR SYSTEM, ANNUAL REVIEW OF CELL BIOLOGY 1: 1 (1985). (10.1146/annurev.cb.01.110185.000245) / ANNUAL REVIEW OF CELL BIOLOGY (1985)
GRAY, A, NUCLEOTIDE-SEQUENCE OF EPIDERMAL GROWTH-FACTOR CDNA PREDICTS A 128,000-MOLECULAR WEIGHT PROTEIN-PRECURSOR, NATURE 303: 722 (1983). (10.1038/303722a0) / NATURE (1983)
Gutmann, J., American Journal of Physiology - Cell Physiology 257: C397 (1989). (10.1152/ajpcell.1989.257.2.C397) / American Journal of Physiology - Cell Physiology (1989)
HERZ, J, SURFACE LOCATION AND HIGH-AFFINITY FOR CALCIUM OF A 500-KD LIVER MEMBRANE-PROTEIN CLOSELY RELATED TO THE LDL-RECEPTOR SUGGEST A PHYSIOLOGICAL-ROLE AS LIPOPROTEIN RECEPTOR, EMBO JOURNAL 7: 4119 (1988). (10.1002/j.1460-2075.1988.tb03306.x) / EMBO JOURNAL (1988)
HEYMANN, W, PRODUCTION OF NEPHROTIC SYNDROME IN RATS BY FREUND ADJUVANTS AND RAT KIDNEY SUSPENSIONS, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 100: 660 (1959). (10.3181/00379727-100-24736) / PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE (1959)
HOUGHTEN, R.A., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 5231 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
HOWARD, OMZ, COMPLEMENTARY-DNA AND DERIVED AMINO-ACID-SEQUENCE OF THE BETA-SUBUNIT OF HUMAN-COMPLEMENT PROTEIN C8 - IDENTIFICATION OF A CLOSE STRUCTURAL AND ANCESTRAL RELATIONSHIP TO THE ALPHA-SUBUNIT AND C9, BIOCHEMISTRY 26: 3565 (1987). (10.1021/bi00386a047) / BIOCHEMISTRY (1987)
Huynh, T. V., DNA Cloning: A Practical Approach 1: 49 (1985). / DNA Cloning: A Practical Approach (1985)
KAMATA, K, CHARACTERIZATION OF ANTIGENS AND ANTIBODY SPECIFICITIES INVOLVED IN HEYMANN NEPHRITIS, JOURNAL OF IMMUNOLOGY 135: 2400 (1985). (10.4049/jimmunol.135.4.2400) / JOURNAL OF IMMUNOLOGY (1985)
KERJASCHKI, D, IDENTIFICATION OF A 400-KD PROTEIN IN THE BRUSH-BORDERS OF HUMAN-KIDNEY TUBULES THAT IS SIMILAR TO GP330, THE NEPHRITOGENIC ANTIGEN OF RAT HEYMANN NEPHRITIS, AMERICAN JOURNAL OF PATHOLOGY 129: 183 (1987). / AMERICAN JOURNAL OF PATHOLOGY (1987)
KERJASCHKI, D, IMMUNOCYTOCHEMICAL LOCALIZATION OF THE HEYMANN NEPHRITIS ANTIGEN (GP330) IN GLOMERULAR EPITHELIAL-CELLS OF NORMAL LEWIS RATS, JOURNAL OF EXPERIMENTAL MEDICINE 157: 667 (1983). (10.1084/jem.157.2.667) / JOURNAL OF EXPERIMENTAL MEDICINE (1983)
KERJASCHKI, D, THE PATHOGENIC ANTIGEN OF HEYMANN NEPHRITIS IS A MEMBRANE GLYCOPROTEIN OF THE RENAL PROXIMAL TUBULE BRUSH-BORDER, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 5557 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)
10.1126/science.2983426
MCCLELLAND, A, THE HUMAN TRANSFERRIN RECEPTOR GENE - GENOMIC ORGANIZATION, AND THE COMPLETE PRIMARY STRUCTURE OF THE RECEPTOR DEDUCED FROM A CDNA SEQUENCE, CELL 39: 267 (1984). (10.1016/0092-8674(84)90004-7) / CELL (1984)
MOSTOV, K.E., THE RECEPTOR FOR TRANS-EPITHELIAL TRANSPORT OF IGA AND IGM CONTAINS MULTIPLE IMMUNOGLOBULIN-LIKE DOMAINS, NATURE 308: 37 (1984). (10.1038/308037a0) / NATURE (1984)
NAKALAS, J.J., J IMMUNOL 141: 4152 (1988). (10.4049/jimmunol.141.12.4152) / J IMMUNOL (1988)
NILES, J, KIDNEY INTERNATIONAL 31: 338 (1987). / KIDNEY INTERNATIONAL (1987)
RAO, A.G., COMPLEMENTARY-DNA AND DERIVED AMINO-ACID-SEQUENCE OF THE ALPHA-SUBUNIT OF HUMAN-COMPLEMENT PROTEIN C8 - EVIDENCE FOR THE EXISTENCE OF A SEPARATE ALPHA-SUBUNIT MESSENGER-RNA, BIOCHEMISTRY 26: 3556 (1987). (10.1021/bi00386a046) / BIOCHEMISTRY (1987)
SANGER, F, RAPID METHOD FOR DETERMINING SEQUENCES IN DNA BY PRIMED SYNTHESIS WITH DNA-POLYMERASE, JOURNAL OF MOLECULAR BIOLOGY 94: 441 (1975). (10.1016/0022-2836(75)90213-2) / JOURNAL OF MOLECULAR BIOLOGY (1975)
SCHNEIDER, C, PRIMARY STRUCTURE OF HUMAN TRANSFERRIN RECEPTOR DEDUCED FROM THE MESSENGER-RNA SEQUENCE, NATURE 311: 675 (1984). / NATURE (1984)
10.1126/science.6602382
STANLEY, K.K., THE SEQUENCE AND TOPOLOGY OF HUMAN-COMPLEMENT COMPONENT C9, EMBO JOURNAL 4: 375 (1985). (10.1002/j.1460-2075.1985.tb03639.x) / EMBO JOURNAL (1985)
ULLRICH, A, HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR CDNA SEQUENCE AND ABERRANT EXPRESSION OF THE AMPLIFIED GENE IN A431 EPIDERMOID CARCINOMA-CELLS, NATURE 309: 418 (1984). (10.1038/309418a0) / NATURE (1984)
WONG, W.W., IDENTIFICATION OF A PARTIAL CDNA CLONE FOR THE HUMAN RECEPTOR FOR COMPLEMENT FRAGMENTS C3B/C4B, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 7711 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
YAMAMOTO, T, THE HUMAN LDL RECEPTOR - A CYSTEINE-RICH PROTEIN WITH MULTIPLE ALU SEQUENCES IN ITS MESSENGER-RNA, CELL 39: 27 (1984). (10.1016/0092-8674(84)90188-0) / CELL (1984)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 11:40 p.m.)
Indexed	3 days, 6 hours ago (Aug. 23, 2025, 1:02 a.m.)
Issued	36 years, 2 months ago (June 9, 1989)
Published	36 years, 2 months ago (June 9, 1989)
Published Print	36 years, 2 months ago (June 9, 1989)

Funders 0

None

BibTeX

@article{Raychowdhury_1989, title={Autoimmune Target in Heymann Nephritis Is a Glycoprotein with Homology to the LDL Receptor}, volume={244}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2786251}, DOI={10.1126/science.2786251}, number={4909}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Raychowdhury, Raktima and Niles, John L. and McCluskey, Robert T. and Smith, John A.}, year={1989}, month=jun, pages={1163–1165} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        23
      ]
    ],
    "date-time": "2025-08-23T05:02:34Z",
    "timestamp": 1755925354484
  },
  "reference-count": 31,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4909",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1989,
        6,
        9
      ]
    ]
  },
  "abstract": "<jats:p>The pathogenesis of Heymann nephritis, a rat model of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal glycoprotein (GP330) on glomerular podocytes. Partial complementary DNAs coding for GP330 were isolated and sequenced. The deduced amino acid sequence from 4.3 kilobases of complementary DNA contains the sequences identical to two peptides derived from the isolated glycoprotein. The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family. Autoantibodies from the kidneys of rats with Heymann nephritis reacted with a nonglycosylated segment of GP330 that contains cysteine-rich 40-amino acid repeats, which are also features of the LDL receptor. GP330 is also similar in some regions to the mouse epidermal growth factor precursor.</jats:p>",
  "DOI": "10.1126/science.2786251",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T21:21:28Z",
    "timestamp": 1160083288000
  },
  "page": "1163-1165",
  "source": "Crossref",
  "is-referenced-by-count": 188,
  "title": "Autoimmune Target in Heymann Nephritis Is a Glycoprotein with Homology to the LDL Receptor",
  "prefix": "10.1126",
  "volume": "244",
  "author": [
    {
      "given": "Raktima",
      "family": "Raychowdhury",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Pathology, Massachusetts General Hospital, Boston, MA 02114."
        },
        {
          "name": "Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114."
        }
      ]
    },
    {
      "given": "John L.",
      "family": "Niles",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pathology, Massachusetts General Hospital, Boston, MA 02114."
        },
        {
          "name": "Department of Medicine, Massachusetts General Hospital, Boston, MA 02114."
        }
      ]
    },
    {
      "given": "Robert T.",
      "family": "McCluskey",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pathology, Massachusetts General Hospital, Boston, MA 02114."
        }
      ]
    },
    {
      "given": "John A.",
      "family": "Smith",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pathology, Massachusetts General Hospital, Boston, MA 02114."
        },
        {
          "name": "Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "doi-asserted-by": "crossref",
      "first-page": "12395",
      "DOI": "10.1016/S0021-9258(18)67253-9",
      "volume": "261",
      "year": "1986",
      "unstructured": "BAI, D.H., MOLECULAR-CLONING OF CDNA FOR ACETYL-COENZYME-A CARBOXYLASE, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 12395 (1986).",
      "journal-title": "JOURNAL OF BIOLOGICAL CHEMISTRY"
    },
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "first-page": "2409",
      "DOI": "10.4049/jimmunol.135.4.2409",
      "volume": "135",
      "year": "1985",
      "unstructured": "CAMUSSI, G, ANTIBODY-INDUCED REDISTRIBUTION OF HEYMANN ANTIGEN ON THE SURFACE OF CULTURED GLOMERULAR VISCERAL EPITHELIAL-CELLS - POSSIBLE ROLE IN THE PATHOGENESIS OF HEYMANN GLOMERULONEPHRITIS, JOURNAL OF IMMUNOLOGY 135: 2409 (1985).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_3_1",
      "first-page": "512",
      "volume": "122",
      "year": "1986",
      "unstructured": "CHATELET, F, ULTRASTRUCTURAL-LOCALIZATION BY MONOCLONAL-ANTIBODIES OF BRUSH-BORDER ANTIGENS EXPRESSED BY GLOMERULI .2. EXTRARENAL DISTRIBUTION, AMERICAN JOURNAL OF PATHOLOGY 122: 512 (1986).",
      "journal-title": "AMERICAN JOURNAL OF PATHOLOGY"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/12.1Part1.387"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "crossref",
      "first-page": "A178",
      "DOI": "10.1083/jcb.97.1.178",
      "volume": "97",
      "year": "1983",
      "unstructured": "DOXSEY, S, A LARGE MEMBRANE GLYCOPROTEIN (GP330) IS A RESIDENT OF COATED PITS OF SEVERAL ABSORBTIVE EPITHELIA, JOURNAL OF CELL BIOLOGY 97: A178 (1983).",
      "journal-title": "JOURNAL OF CELL BIOLOGY"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "770",
      "DOI": "10.1016/S0021-9258(17)43524-1",
      "volume": "259",
      "year": "1984",
      "unstructured": "DRICKAMER, K, PRIMARY STRUCTURE OF THE RAT-LIVER ASIALOGLYCOPROTEIN RECEPTOR - STRUCTURAL EVIDENCE FOR MULTIPLE POLYPEPTIDE SPECIES, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 770 (1984).",
      "journal-title": "JOURNAL OF BIOLOGICAL CHEMISTRY"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1146/annurev.cb.01.110185.000245",
      "volume": "1",
      "year": "1985",
      "unstructured": "GOLDSTEIN, J.L., RECEPTOR-MEDIATED ENDOCYTOSIS - CONCEPTS EMERGING FROM THE LDL RECEPTOR SYSTEM, ANNUAL REVIEW OF CELL BIOLOGY 1: 1 (1985).",
      "journal-title": "ANNUAL REVIEW OF CELL BIOLOGY"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "crossref",
      "first-page": "722",
      "DOI": "10.1038/303722a0",
      "volume": "303",
      "year": "1983",
      "unstructured": "GRAY, A, NUCLEOTIDE-SEQUENCE OF EPIDERMAL GROWTH-FACTOR CDNA PREDICTS A 128,000-MOLECULAR WEIGHT PROTEIN-PRECURSOR, NATURE 303: 722 (1983).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "crossref",
      "first-page": "C397",
      "DOI": "10.1152/ajpcell.1989.257.2.C397",
      "volume": "257",
      "year": "1989",
      "unstructured": "Gutmann, J., American Journal of Physiology - Cell Physiology 257: C397 (1989).",
      "journal-title": "American Journal of Physiology - Cell Physiology"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "crossref",
      "first-page": "4119",
      "DOI": "10.1002/j.1460-2075.1988.tb03306.x",
      "volume": "7",
      "year": "1988",
      "unstructured": "HERZ, J, SURFACE LOCATION AND HIGH-AFFINITY FOR CALCIUM OF A 500-KD LIVER MEMBRANE-PROTEIN CLOSELY RELATED TO THE LDL-RECEPTOR SUGGEST A PHYSIOLOGICAL-ROLE AS LIPOPROTEIN RECEPTOR, EMBO JOURNAL 7: 4119 (1988).",
      "journal-title": "EMBO JOURNAL"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "660",
      "DOI": "10.3181/00379727-100-24736",
      "volume": "100",
      "year": "1959",
      "unstructured": "HEYMANN, W, PRODUCTION OF NEPHROTIC SYNDROME IN RATS BY FREUND ADJUVANTS AND RAT KIDNEY SUSPENSIONS, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 100: 660 (1959).",
      "journal-title": "PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"
    },
    {
      "key": "e_1_2_1_12_1",
      "first-page": "5231",
      "volume": "82",
      "year": "1985",
      "unstructured": "HOUGHTEN, R.A., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 5231 (1985).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "3565",
      "DOI": "10.1021/bi00386a047",
      "volume": "26",
      "year": "1987",
      "unstructured": "HOWARD, OMZ, COMPLEMENTARY-DNA AND DERIVED AMINO-ACID-SEQUENCE OF THE BETA-SUBUNIT OF HUMAN-COMPLEMENT PROTEIN C8 - IDENTIFICATION OF A CLOSE STRUCTURAL AND ANCESTRAL RELATIONSHIP TO THE ALPHA-SUBUNIT AND C9, BIOCHEMISTRY 26: 3565 (1987).",
      "journal-title": "BIOCHEMISTRY"
    },
    {
      "key": "e_1_2_1_14_1",
      "first-page": "49",
      "volume": "1",
      "year": "1985",
      "unstructured": "Huynh, T. V., DNA Cloning: A Practical Approach 1: 49 (1985).",
      "journal-title": "DNA Cloning: A Practical Approach"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "crossref",
      "first-page": "2400",
      "DOI": "10.4049/jimmunol.135.4.2400",
      "volume": "135",
      "year": "1985",
      "unstructured": "KAMATA, K, CHARACTERIZATION OF ANTIGENS AND ANTIBODY SPECIFICITIES INVOLVED IN HEYMANN NEPHRITIS, JOURNAL OF IMMUNOLOGY 135: 2400 (1985).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_16_1",
      "first-page": "183",
      "volume": "129",
      "year": "1987",
      "unstructured": "KERJASCHKI, D, IDENTIFICATION OF A 400-KD PROTEIN IN THE BRUSH-BORDERS OF HUMAN-KIDNEY TUBULES THAT IS SIMILAR TO GP330, THE NEPHRITOGENIC ANTIGEN OF RAT HEYMANN NEPHRITIS, AMERICAN JOURNAL OF PATHOLOGY 129: 183 (1987).",
      "journal-title": "AMERICAN JOURNAL OF PATHOLOGY"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "first-page": "667",
      "DOI": "10.1084/jem.157.2.667",
      "volume": "157",
      "year": "1983",
      "unstructured": "KERJASCHKI, D, IMMUNOCYTOCHEMICAL LOCALIZATION OF THE HEYMANN NEPHRITIS ANTIGEN (GP330) IN GLOMERULAR EPITHELIAL-CELLS OF NORMAL LEWIS RATS, JOURNAL OF EXPERIMENTAL MEDICINE 157: 667 (1983).",
      "journal-title": "JOURNAL OF EXPERIMENTAL MEDICINE"
    },
    {
      "key": "e_1_2_1_18_1",
      "first-page": "5557",
      "volume": "79",
      "year": "1982",
      "unstructured": "KERJASCHKI, D, THE PATHOGENIC ANTIGEN OF HEYMANN NEPHRITIS IS A MEMBRANE GLYCOPROTEIN OF THE RENAL PROXIMAL TUBULE BRUSH-BORDER, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 5557 (1982).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2983426"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "267",
      "DOI": "10.1016/0092-8674(84)90004-7",
      "volume": "39",
      "year": "1984",
      "unstructured": "MCCLELLAND, A, THE HUMAN TRANSFERRIN RECEPTOR GENE - GENOMIC ORGANIZATION, AND THE COMPLETE PRIMARY STRUCTURE OF THE RECEPTOR DEDUCED FROM A CDNA SEQUENCE, CELL 39: 267 (1984).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1038/308037a0",
      "volume": "308",
      "year": "1984",
      "unstructured": "MOSTOV, K.E., THE RECEPTOR FOR TRANS-EPITHELIAL TRANSPORT OF IGA AND IGM CONTAINS MULTIPLE IMMUNOGLOBULIN-LIKE DOMAINS, NATURE 308: 37 (1984).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "crossref",
      "first-page": "4152",
      "DOI": "10.4049/jimmunol.141.12.4152",
      "volume": "141",
      "year": "1988",
      "unstructured": "NAKALAS, J.J., J IMMUNOL 141: 4152 (1988).",
      "journal-title": "J IMMUNOL"
    },
    {
      "key": "e_1_2_1_23_1",
      "first-page": "338",
      "volume": "31",
      "year": "1987",
      "unstructured": "NILES, J, KIDNEY INTERNATIONAL 31: 338 (1987).",
      "journal-title": "KIDNEY INTERNATIONAL"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "3556",
      "DOI": "10.1021/bi00386a046",
      "volume": "26",
      "year": "1987",
      "unstructured": "RAO, A.G., COMPLEMENTARY-DNA AND DERIVED AMINO-ACID-SEQUENCE OF THE ALPHA-SUBUNIT OF HUMAN-COMPLEMENT PROTEIN C8 - EVIDENCE FOR THE EXISTENCE OF A SEPARATE ALPHA-SUBUNIT MESSENGER-RNA, BIOCHEMISTRY 26: 3556 (1987).",
      "journal-title": "BIOCHEMISTRY"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "crossref",
      "first-page": "441",
      "DOI": "10.1016/0022-2836(75)90213-2",
      "volume": "94",
      "year": "1975",
      "unstructured": "SANGER, F, RAPID METHOD FOR DETERMINING SEQUENCES IN DNA BY PRIMED SYNTHESIS WITH DNA-POLYMERASE, JOURNAL OF MOLECULAR BIOLOGY 94: 441 (1975).",
      "journal-title": "JOURNAL OF MOLECULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_26_1",
      "first-page": "675",
      "volume": "311",
      "year": "1984",
      "unstructured": "SCHNEIDER, C, PRIMARY STRUCTURE OF HUMAN TRANSFERRIN RECEPTOR DEDUCED FROM THE MESSENGER-RNA SEQUENCE, NATURE 311: 675 (1984).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.6602382"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1002/j.1460-2075.1985.tb03639.x",
      "volume": "4",
      "year": "1985",
      "unstructured": "STANLEY, K.K., THE SEQUENCE AND TOPOLOGY OF HUMAN-COMPLEMENT COMPONENT C9, EMBO JOURNAL 4: 375 (1985).",
      "journal-title": "EMBO JOURNAL"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "crossref",
      "first-page": "418",
      "DOI": "10.1038/309418a0",
      "volume": "309",
      "year": "1984",
      "unstructured": "ULLRICH, A, HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR CDNA SEQUENCE AND ABERRANT EXPRESSION OF THE AMPLIFIED GENE IN A431 EPIDERMOID CARCINOMA-CELLS, NATURE 309: 418 (1984).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_30_1",
      "first-page": "7711",
      "volume": "82",
      "year": "1985",
      "unstructured": "WONG, W.W., IDENTIFICATION OF A PARTIAL CDNA CLONE FOR THE HUMAN RECEPTOR FOR COMPLEMENT FRAGMENTS C3B/C4B, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 7711 (1985).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "crossref",
      "first-page": "27",
      "DOI": "10.1016/0092-8674(84)90188-0",
      "volume": "39",
      "year": "1984",
      "unstructured": "YAMAMOTO, T, THE HUMAN LDL RECEPTOR - A CYSTEINE-RICH PROTEIN WITH MULTIPLE ALU SEQUENCES IN ITS MESSENGER-RNA, CELL 39: 27 (1984).",
      "journal-title": "CELL"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.2786251",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        13
      ]
    ],
    "date-time": "2024-01-13T04:40:10Z",
    "timestamp": 1705120810000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.2786251"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1989,
        6,
        9
      ]
    ]
  },
  "references-count": 31,
  "journal-issue": {
    "issue": "4909",
    "published-print": {
      "date-parts": [
        [
          1989,
          6,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.2786251"
  ],
  "URL": "http://dx.doi.org/10.1126/science.2786251",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1989,
        6,
        9
      ]
    ]
  }
}