DOI: 10.1126/science.2781279. Molecular Structure of DNA by Scanning Tunneling Microscopy

Molecular Structure of DNA by Scanning Tunneling Microscopy

10.1126/science.2781279

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Uncoated DNA molecules marked with an activated tris(1-aziridinyl) phosphine oxide (TAPO) solution were deposited on gold substrates and imaged in air with the use of a high-resolution scanning tunneling microscope (STM). Constant-current and gap-modulated STM images show clear evidence of the helicity of the DNA structure: pitch periodicity ranges from 25 and 35 angstroms, whereas the average diameter is 20 angstroms. Molecular structure within a single helix turn was also observed.

Bibliography

Cricenti, A., Selci, S., Felici, A. C., Generosi, R., Gori, E., Djaczenko, W., & Chiarotti, G. (1989). Molecular Structure of DNA by Scanning Tunneling Microscopy. Science, 245(4923), 1226â1227.

Authors 7

A. Cricenti (first)
S. Selci (additional)
A. C. Felici (additional)
R. Generosi (additional)
E. Gori (additional)
W. Djaczenko (additional)
G. Chiarotti (additional)

References 13 Referenced 66

10.1126/science.3358130
BARO, A.M., DETERMINATION OF SURFACE-TOPOGRAPHY OF BIOLOGICAL SPECIMENS AT HIGH-RESOLUTION BY SCANNING TUNNELLING MICROSCOPY, NATURE 315: 253 (1985). (10.1038/315253a0) / NATURE (1985)
BEEBE, T.P., DIRECT OBSERVATION OF NATIVE DNA STRUCTURES WITH THE SCANNING TUNNELING MICROSCOPE, SCIENCE 243: 370 (1989). (10.1126/science.2911747) / SCIENCE (1989)
BINNIG, G, SCANNING TUNNELING MICROSCOPY, IBM JOURNAL OF RESEARCH AND DEVELOPMENT 30: 355 (1986). / IBM JOURNAL OF RESEARCH AND DEVELOPMENT (1986)
BINNIG, G, 7X7 RECONSTRUCTION ON SI(111) RESOLVED IN REAL SPACE, PHYSICAL REVIEW LETTERS 50: 120 (1983). (10.1103/PhysRevLett.50.120) / PHYSICAL REVIEW LETTERS (1983)
CRICENTI, A, JOURNAL OF MICROSCOPY 152: 789 (1988). (10.1111/j.1365-2818.1988.tb01450.x) / JOURNAL OF MICROSCOPY (1988)
CRICENTI, A, SHAPING OF TUNGSTEN TIPS FOR SCANNING TUNNELING MICROSCOPE, SOLID STATE COMMUNICATIONS 70: 897 (1989). (10.1016/0038-1098(89)90290-1) / SOLID STATE COMMUNICATIONS (1989)
DJACZENKO, W, VISUALIZATION OF POLYSACCHARIDES IN CUTICLE OF OLIGOCHAETA BY TRIS 1-AZIRIDINYL PHOSPHINE OXIDE METHOD - DEMONSTRATION OF 62.5 AND 185 A PERIODICITIES IN CUTICULAR FIBERS, JOURNAL OF CELL BIOLOGY 57: 859 (1973). (10.1083/jcb.57.3.859) / JOURNAL OF CELL BIOLOGY (1973)
MARCHON, B, ATOMIC ARRANGEMENT OF SULFUR ADATOMS ON MO(001) AT ATMOSPHERIC-PRESSURE - A SCANNING TUNNELING MICROSCOPY STUDY, PHYSICAL REVIEW LETTERS 60: 1166 (1988). (10.1103/PhysRevLett.60.1166) / PHYSICAL REVIEW LETTERS (1988)
SELCI, S, INSTITUTE OF PHYSICS CONFERENCE SERIES 93: 281 (1988). / INSTITUTE OF PHYSICS CONFERENCE SERIES (1988)
SELCI, S, NEW AIR OPERATING SCANNING TUNNELING MICROSCOPE, SURFACE SCIENCE 211: 143 (1989). / SURFACE SCIENCE (1989)
TRAVAGLINI, G, SCANNING TUNNELING MICROSCOPY ON BIOLOGICAL MATTER, SURFACE SCIENCE 181: 380 (1987). (10.1016/0039-6028(87)90181-6) / SURFACE SCIENCE (1987)
10.1126/science.3344420

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 12:36 a.m.)
Indexed	1 year ago (Sept. 4, 2024, 9:42 a.m.)
Issued	35 years, 11 months ago (Sept. 15, 1989)
Published	35 years, 11 months ago (Sept. 15, 1989)
Published Print	35 years, 11 months ago (Sept. 15, 1989)

Funders 0

None

BibTeX

@article{Cricenti_1989, title={Molecular Structure of DNA by Scanning Tunneling Microscopy}, volume={245}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2781279}, DOI={10.1126/science.2781279}, number={4923}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cricenti, A. and Selci, S. and Felici, A. C. and Generosi, R. and Gori, E. and Djaczenko, W. and Chiarotti, G.}, year={1989}, month=sep, pages={1226–1227} }

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