Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
10.1126/science.278.5343.1623
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

A lymphocyte subpopulation, the V α 14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the V α 14 and J α 281 gene segments. Mice with a deletion of the J α 281 gene segment were found to exclusively lack this subpopulation. The V α 14 NKT cell–deficient mice could no longer mediate the interleukin-12 (IL-12)–induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, V α 14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12.

Bibliography

Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M. (1997). Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors. Science, 278(5343), 1623–1626.

Authors 10
  1. Junqing Cui (first)
  2. Tahiro Shin (additional)
  3. Tetsu Kawano (additional)
  4. Hiroshi Sato (additional)
  5. Eisuke Kondo (additional)
  6. Isao Toura (additional)
  7. Yoshikatsu Kaneko (additional)
  8. Haruhiko Koseki (additional)
  9. Masamoto Kanno (additional)
  10. Masaru Taniguchi (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:45 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 11:46 p.m.)
Indexed 1 week ago (Aug. 23, 2025, 12:59 a.m.)
Issued 27 years, 9 months ago (Nov. 28, 1997)
Published 27 years, 9 months ago (Nov. 28, 1997)
Published Print 27 years, 9 months ago (Nov. 28, 1997)
Funders 0

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@article{Cui_1997, title={Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors}, volume={278}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.278.5343.1623}, DOI={10.1126/science.278.5343.1623}, number={5343}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cui, Junqing and Shin, Tahiro and Kawano, Tetsu and Sato, Hiroshi and Kondo, Eisuke and Toura, Isao and Kaneko, Yoshikatsu and Koseki, Haruhiko and Kanno, Masamoto and Taniguchi, Masaru}, year={1997}, month=nov, pages={1623–1626} }