Genetics of Aging
10.1126/science.278.5337.407
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The role of genetics in determining life-span is complex and paradoxical. Although the heritability of life-span is relatively minor, some genetic variants significantly modify senescence of mammals and invertebrates, with both positive and negative impacts on age-related disorders and life-spans. In certain examples, the gene variants alter metabolic pathways, which could thereby mediate interactions with nutritional and other environmental factors that influence life-span. Given the relatively minor effect and variable penetrance of genetic risk factors that appear to affect survival and health at advanced ages, life-style and other environmental influences may profoundly modify outcomes of aging.

Bibliography

Finch, C. E., & Tanzi, R. E. (1997). Genetics of Aging. Science, 278(5337), 407–411.

Authors 2
  1. Caleb E. Finch (first)
  2. Rudolph E. Tanzi (additional)
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  91. These projects were supported by grants from the National Institute on Aging (C.E.F. and R.E.T.) the National Institute of Neurological Disorders and Stroke (R.E.T.) and the Metropolitan Life Foundation (R.E.T.). T. Johnson G. McClearn R. Miller M. Tater and J. Tower gave helpful comments.
Dates
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Created 23 years, 1 month ago (July 27, 2002, 5:50 a.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 12:32 a.m.)
Indexed 3 days, 21 hours ago (Aug. 31, 2025, 6:28 a.m.)
Issued 27 years, 10 months ago (Oct. 17, 1997)
Published 27 years, 10 months ago (Oct. 17, 1997)
Published Print 27 years, 10 months ago (Oct. 17, 1997)
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@article{Finch_1997, title={Genetics of Aging}, volume={278}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.278.5337.407}, DOI={10.1126/science.278.5337.407}, number={5337}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Finch, Caleb E. and Tanzi, Rudolph E.}, year={1997}, month=oct, pages={407–411} }