In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development
10.1126/science.277.5329.1103
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Signaling cascades triggered by receptor tyrosine kinases (RTKs) participate in diverse developmental processes. The active state of these signaling pathways was monitored by examination of the in situ distribution of the active, dual phosphorylated form of mitogen-activated protein kinase (ERK) with a specific monoclonal antibody. Detection of the active state of the Drosophila epidermal growth factor receptor (DER) pathway allowed the visualization of gradients and boundaries of receptor activation, assessment of the distribution of activating ligands, and analysis of interplay with the inhibitory ligand Argos. This in situ approach can be used to monitor other receptor-triggered pathways in a wide range of organisms.

Bibliography

Gabay, L., Seger, R., & Shilo, B.-Z. (1997). In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development. Science, 277(5329), 1103–1106.

Authors 3
  1. Limor Gabay (first)
  2. Rony Seger (additional)
  3. Ben-Zion Shilo (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:44 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 10:22 p.m.)
Indexed 2 weeks, 3 days ago (Aug. 19, 2025, 6:14 a.m.)
Issued 28 years ago (Aug. 22, 1997)
Published 28 years ago (Aug. 22, 1997)
Published Print 28 years ago (Aug. 22, 1997)
Funders 0

None

@article{Gabay_1997, title={In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development}, volume={277}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.277.5329.1103}, DOI={10.1126/science.277.5329.1103}, number={5329}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Gabay, Limor and Seger, Rony and Shilo, Ben-Zion}, year={1997}, month=aug, pages={1103–1106} }