An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons
10.1126/science.277.5329.1097
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Nerve growth factor (NGF) is a neurotrophic factor secreted by cells that are the targets of innervation of sympathetic and some sensory neurons. However, the mechanism by which the NGF signal is propagated from the axon terminal to the cell body, which can be more than 1 meter away, to influence biochemical events critical for growth and survival of neurons has remained unclear. An NGF-mediated signal transmitted from the terminals and distal axons of cultured rat sympathetic neurons to their nuclei regulated phosphorylation of the transcription factor CREB (cyclic adenosine monophosphate response element – binding protein). Internalization of NGF and its receptor tyrosine kinase TrkA, and their transport to the cell body, were required for transmission of this signal. The tyrosine kinase activity of TrkA was required to maintain it in an autophosphorylated state upon its arrival in the cell body and for propagation of the signal to CREB within neuronal nuclei. Thus, an NGF-TrkA complex is a messenger that delivers the NGF signal from axon terminals to cell bodies of sympathetic neurons.

Bibliography

Riccio, A., Pierchala, B. A., Ciarallo, C. L., & Ginty, D. D. (1997). An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons. Science, 277(5329), 1097–1100.

Authors 4
  1. Antonella Riccio (first)
  2. Brian A. Pierchala (additional)
  3. Christopher L. Ciarallo (additional)
  4. David D. Ginty (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:44 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 10:23 p.m.)
Indexed 59 minutes ago (Aug. 29, 2025, 6:27 a.m.)
Issued 28 years ago (Aug. 22, 1997)
Published 28 years ago (Aug. 22, 1997)
Published Print 28 years ago (Aug. 22, 1997)
Funders 0

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@article{Riccio_1997, title={An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons}, volume={277}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.277.5329.1097}, DOI={10.1126/science.277.5329.1097}, number={5329}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Riccio, Antonella and Pierchala, Brian A. and Ciarallo, Christopher L. and Ginty, David D.}, year={1997}, month=aug, pages={1097–1100} }