DOI: 10.1126/science.277.5327.812. Sensitization to Morphine Induced by Viral-Mediated Gene Transfer

Sensitization to Morphine Induced by Viral-Mediated Gene Transfer

10.1126/science.277.5327.812

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It also selectively increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area, a midbrain region implicated in morphine action. By viral-mediated gene transfer, a causal relation is shown between these behavioral and biochemical adaptations: Morphine's stimulant and rewarding properties are intensified after microinjections of a viral vector expressing GluR1 into the ventral tegmental area. These results confirm the importance of AMPA receptors in morphine action and demonstrate specific locomotor and motivational adaptations resulting from altered expression of a single localized gene product.

Bibliography

Carlezon, W. A., Boundy, V. A., Haile, C. N., Lane, S. B., Kalb, R. G., Neve, R. L., & Nestler, E. J. (1997). Sensitization to Morphine Induced by Viral-Mediated Gene Transfer. Science, 277(5327), 812â815.

Authors 7

William A. Carlezon (first)
Virginia A. Boundy (additional)
Colin N. Haile (additional)
Sarah B. Lane (additional)
Robert G. Kalb (additional)
Rachael L. Neve (additional)
Eric J. Nestler (additional)

References 46 Referenced 213

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Supported by grants (to E.J.N.) and a fellowship (to W.A.C.) from the National Institute on Drug Abuse (USA) and grants (to R.G.K. and R.L.N.) from the National Institutes of Health. We thank N. Hiroi for his contributions.

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:44 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 12:55 a.m.)
Indexed	1 year, 1 month ago (July 30, 2024, 3:49 p.m.)
Issued	28 years ago (Aug. 8, 1997)
Published	28 years ago (Aug. 8, 1997)
Published Print	28 years ago (Aug. 8, 1997)

Funders 0

None

BibTeX

@article{Carlezon_1997, title={Sensitization to Morphine Induced by Viral-Mediated Gene Transfer}, volume={277}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.277.5327.812}, DOI={10.1126/science.277.5327.812}, number={5327}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Carlezon, William A. and Boundy, Virginia A. and Haile, Colin N. and Lane, Sarah B. and Kalb, Robert G. and Neve, Rachael L. and Nestler, Eric J.}, year={1997}, month=aug, pages={812–815} }

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