Localization of Xenopus Vg1 mRNA by Vera Protein and the Endoplasmic Reticulum
10.1126/science.276.5315.1128
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus , the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3′ untranslated region and the ER subcompartment.

Bibliography

Deshler, J. O., Highett, M. I., & Schnapp, B. J. (1997). Localization of Xenopus Vg1 mRNA by Vera Protein and the Endoplasmic Reticulum. Science, 276(5315), 1128–1131.

Authors 3
  1. James O. Deshler (first)
  2. Martin I. Highett (additional)
  3. Bruce J. Schnapp (additional)
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Dates
Type When
Created 23 years ago (July 27, 2002, 5:45 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 11:07 p.m.)
Indexed 1 month, 2 weeks ago (July 11, 2025, 6:21 a.m.)
Issued 28 years, 3 months ago (May 16, 1997)
Published 28 years, 3 months ago (May 16, 1997)
Published Print 28 years, 3 months ago (May 16, 1997)
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@article{Deshler_1997, title={Localization of Xenopus Vg1 mRNA by Vera Protein and the Endoplasmic Reticulum}, volume={276}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.276.5315.1128}, DOI={10.1126/science.276.5315.1128}, number={5315}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Deshler, James O. and Highett, Martin I. and Schnapp, Bruce J.}, year={1997}, month=may, pages={1128–1131} }