DOI: 10.1126/science.276.5310.264. Separate Neural Bases of Two Fundamental Memory Processes in the Human Medial Temporal Lobe

Separate Neural Bases of Two Fundamental Memory Processes in the Human Medial Temporal Lobe

10.1126/science.276.5310.264

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The participation of medial temporal-lobe structures in memory performance was examined by functional magnetic resonance imaging of local blood oxygenation level–dependent signals. Signals were measured during encoding into memory complex scenes or line drawings and during retrieval from memory of previously studied line drawings or words. Encoding tasks yielded increased signals for unfamiliar information in a posterior medial-temporal region that were focused in the parahippocampal cortex. Retrieval tasks yielded increased signals for successfully remembered information in an anterior medial-temporal region that were focused in the subiculum. These results indicate that separate components of the human medial temporal-lobe memory system are active during distinct memory processes.

Bibliography

Gabrieli, J. D. E., Brewer, J. B., Desmond, J. E., & Glover, G. H. (1997). Separate Neural Bases of Two Fundamental Memory Processes in the Human Medial Temporal Lobe. Science, 276(5310), 264â266.

Authors 4

John D. E. Gabrieli (first)
James B. Brewer (additional)
John E. Desmond (additional)
Gary H. Glover (additional)

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Supported by grants from the National Institute on Aging and the National Center for Research Resources. J.B.B. was supported by a Medical Scientist Training Program grant awarded by the National Institute of General Medical Sciences. We thank two anonymous reviewers C. Gabrieli L. Marsh L. Stefanacci C. Stern and S. Zola for advice on analyses and this manuscript.

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:37 a.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 10:51 p.m.)
Indexed	1 month ago (July 26, 2025, 5:06 a.m.)
Issued	28 years, 4 months ago (April 11, 1997)
Published	28 years, 4 months ago (April 11, 1997)
Published Print	28 years, 4 months ago (April 11, 1997)

Funders 0

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BibTeX

@article{Gabrieli_1997, title={Separate Neural Bases of Two Fundamental Memory Processes in the Human Medial Temporal Lobe}, volume={276}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.276.5310.264}, DOI={10.1126/science.276.5310.264}, number={5310}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Gabrieli, John D. E. and Brewer, James B. and Desmond, John E. and Glover, Gary H.}, year={1997}, month=apr, pages={264–266} }

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