Involvement of Pre- and Postsynaptic Mechanisms in Posttetanic Potentiation at Aplysia Synapses
10.1126/science.275.5302.969
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Posttetanic potentiation (PTP) is a common form of short-term synaptic plasticity that is generally thought to be entirely presynaptic. Consistent with that idea, PTP of evoked excitatory postsynaptic potentials at Aplysia sensory-motor neuron synapses in cell culture was reduced by presynaptic injection of a slow calcium chelator and was accompanied by an increase in the frequency but not the amplitude of spontaneous excitatory postsynaptic potentials. However, PTP was also reduced by postsynaptic injection of a rapid calcium chelator or postsynaptic hyperpolarization. Thus, PTP at these synapses is likely to involve a postsynaptic induction mechanism in addition to the known presynaptic mechanisms.

Bibliography

Bao, J.-X., Kandel, E. R., & Hawkins, R. D. (1997). Involvement of Pre- and Postsynaptic Mechanisms in Posttetanic Potentiation at Aplysia Synapses. Science, 275(5302), 969–973.

Authors 3
  1. Jian-Xin Bao (first)
  2. Eric R. Kandel (additional)
  3. Robert D. Hawkins (additional)
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  44. Supported by grants from the National Institute of Mental Health (MH 26212) and the Howard Hughes Medical Institute. A long-term fellowship from the Human Frontier Science Program Organization to J.-X.B. is gratefully acknowledged.
Dates
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Created 23 years, 1 month ago (July 27, 2002, 5:45 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 11:05 p.m.)
Indexed 3 months, 1 week ago (May 27, 2025, 1:45 a.m.)
Issued 28 years, 6 months ago (Feb. 14, 1997)
Published 28 years, 6 months ago (Feb. 14, 1997)
Published Print 28 years, 6 months ago (Feb. 14, 1997)
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@article{Bao_1997, title={Involvement of Pre- and Postsynaptic Mechanisms in Posttetanic Potentiation at Aplysia Synapses}, volume={275}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.275.5302.969}, DOI={10.1126/science.275.5302.969}, number={5302}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Bao, Jian-Xin and Kandel, Eric R. and Hawkins, Robert D.}, year={1997}, month=feb, pages={969–973} }