10.1126/science.275.5296.42
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Guanine nucleotide-binding proteins (G proteins) transduce a very large number of cellular regulatory signals. Several recent papers have shown that the larger heterotrimeric G proteins are regulated by a class of molecules known as the RGS proteins (regulators of G protein-signaling family) that are analogous to the GAPs (GTPase activating proteins), which regulate small monomeric G proteins. Iyengar summarizes this evidence and discusses the mechanism of action of the RGS proteins.

Bibliography

Iyengar, R. (1997). There Are GAPS and There Are GAPS. Science, 275(5296), 42–43.

Authors 1
  1. Ravi Iyengar (first)
References 25 Referenced 25
  1. 10.1038/349117a0
  2. Kaziro Y., Biochem. Biophys. Acta. 505, 95 (1978); / Biochem. Biophys. Acta. by Kaziro Y. (1978)
  3. 10.1126/science.2821624
  4. 10.1038/365403a0
  5. Kutuzov M., Pfister C., Eur. J. Biochem. 220, 963 (1994); (10.1111/j.1432-1033.1994.tb18700.x) / Eur. J. Biochem. by Kutuzov M. (1994)
  6. Tang W.-J. , Stanzel M. , Gilman A. G., Biochemistry 34, 14563 (1995); (10.1021/bi00044a035) / Biochemistry by Tang W.-J. (1995)
  7. Taussig R., et al., J. Biol. Chem. 269, 6039 (1994). (10.1016/S0021-9258(17)37574-9) / J. Biol. Chem. by Taussig R. (1994)
  8. Berman D., Wilke T. M., Gilman A. G., Cell 86, 445 (1996). (10.1016/S0092-8674(00)80117-8) / Cell by Berman D. (1996)
  9. Watson N., et al., Nature 383, 175 (1996); (10.1038/383172a0) / Nature by Watson N. (1996)
  10. Hunt T. W., et al., ibid., p. 178. / ibid., by Hunt T. W.
  11. 10.1126/science.271.5252.1056
  12. Dohlman H. G., et al., Mol. Cell. Biol. 15, 3635 (1995); (10.1128/MCB.15.7.3635) / Mol. Cell. Biol. by Dohlman H. G. (1995)
  13. Koelle M. R. and , Horvitz H. R., Cell 84, 115 (1996). (10.1016/S0092-8674(00)80998-8) / Cell by Koelle M. R. (1996)
  14. Druey K. M., et al., Nature 379, 742 (1996). (10.1038/379742a0) / Nature by Druey K. M. (1996)
  15. Kurjan J., Annu. Rev. Genetics. 27, 147 (1993). (10.1146/annurev.ge.27.120193.001051) / Annu. Rev. Genetics. by Kurjan J. (1993)
  16. Higashijima T., et al., J. Biol. Chem. 262, 762 (1987). (10.1016/S0021-9258(19)75851-7) / J. Biol. Chem. by Higashijima T. (1987)
  17. Carty D. J., et al., ibid. 265, 6268 (1987); / ibid. by Carty D. J. (1987)
  18. Linder M. E., et al.,ibid., p. 8283. / ibid., by Linder M. E.
  19. Breitwieser G. E., Szabo G., J. Gen. Physiol. 91, 469 (1988). (10.1085/jgp.91.4.469) / J. Gen. Physiol. by Breitwieser G. E. (1988)
  20. Wang J., et al., J. Biol. Chem.in press. / J. Biol. Chem. by Wang J.
  21. Berman D. M., et al., ibid. 271, 27209 (1996). / ibid. by Berman D. M. (1996)
  22. 10.1126/science.273.5271.115
  23. Scheffzek K., et al., Nature 384, 591 (1996). (10.1038/384591a0) / Nature by Scheffzek K. (1996)
  24. Coleman D. E., et al., Science 265, 1405 (1994); (10.1126/science.8073283) / Science by Coleman D. E. (1994)
  25. Sondek J., et al.,Nature 372, 276 (1994). (10.1038/372276a0) / Nature by Sondek J. (1994)
Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:50 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 10:33 p.m.)
Indexed 1 year, 7 months ago (Jan. 13, 2024, 12:01 a.m.)
Issued 28 years, 7 months ago (Jan. 3, 1997)
Published 28 years, 7 months ago (Jan. 3, 1997)
Published Print 28 years, 7 months ago (Jan. 3, 1997)
Funders 0

None

@article{Iyengar_1997, title={There Are GAPS and There Are GAPS}, volume={275}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.275.5296.42}, DOI={10.1126/science.275.5296.42}, number={5296}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Iyengar, Ravi}, year={1997}, month=jan, pages={42–43} }