DOI: 10.1126/science.274.5295.2100. Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

10.1126/science.274.5295.2100

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Adipocyte differentiation is an important component of obesity and other metabolic diseases. This process is strongly inhibited by many mitogens and oncogenes. Several growth factors that inhibit fat cell differentiation caused mitogen-activated protein (MAP) kinase-mediated phosphorylation of the dominant adipogenic transcription factor peroxisome proliferator-activated receptor γ (PPARγ) and reduction of its transcriptional activity. Expression of PPARγ with a nonphosphorylatable mutation at this site (serine-112) yielded cells with increased sensitivity to ligand-induced adipogenesis and resistance to inhibition of differentiation by mitogens. These results indicate that covalent modification of PPARγ by serum and growth factors is a major regulator of the balance between cell growth and differentiation in the adipose cell lineage.

Bibliography

Hu, E., Kim, J. B., Sarraf, P., & Spiegelman, B. M. (1996). Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARÎ³. Science, 274(5295), 2100â2103.

Authors 4

Erding Hu (first)
Jae Bum Kim (additional)
Pasha Sarraf (additional)
Bruce M. Spiegelman (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:45 a.m.)
Deposited	1 year ago (Aug. 7, 2024, 7:42 a.m.)
Indexed	5 hours, 42 minutes ago (Aug. 30, 2025, 12:29 p.m.)
Issued	28 years, 8 months ago (Dec. 20, 1996)
Published	28 years, 8 months ago (Dec. 20, 1996)
Published Print	28 years, 8 months ago (Dec. 20, 1996)

Funders 0

None

BibTeX

@article{Hu_1996, title={Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ}, volume={274}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.274.5295.2100}, DOI={10.1126/science.274.5295.2100}, number={5295}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hu, Erding and Kim, Jae Bum and Sarraf, Pasha and Spiegelman, Bruce M.}, year={1996}, month=dec, pages={2100–2103} }

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