Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
10.1126/science.274.5293.1739
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar to human MIP chemokines in its ability to inhibit replication of HIV-1 strains dependent on the CCR5 co-receptor. These viral genes may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

Bibliography

Moore, P. S., Boshoff, C., Weiss, R. A., & Chang, Y. (1996). Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV. Science, 274(5293), 1739–1744.

Authors 4
  1. Patrick S. Moore (first)
  2. Chris Boshoff (additional)
  3. Robin A. Weiss (additional)
  4. Yuan Chang (additional)
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Dates
Type When
Created 23 years ago (July 27, 2002, 5:50 a.m.)
Deposited 1 year ago (Aug. 7, 2024, 7:43 a.m.)
Indexed 1 month ago (July 24, 2025, 8:13 a.m.)
Issued 28 years, 8 months ago (Dec. 6, 1996)
Published 28 years, 8 months ago (Dec. 6, 1996)
Published Print 28 years, 8 months ago (Dec. 6, 1996)
Funders 0

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@article{Moore_1996, title={Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV}, volume={274}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.274.5293.1739}, DOI={10.1126/science.274.5293.1739}, number={5293}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Moore, Patrick S. and Boshoff, Chris and Weiss, Robin A. and Chang, Yuan}, year={1996}, month=dec, pages={1739–1744} }