DOI: 10.1126/science.274.5293.1710. Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

10.1126/science.274.5293.1710

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Overexpression of the familial Alzheimer's disease gene Presenilin 2 ( PS2 ) in nerve growth factor-differentiated PC12 cells increased apoptosis induced by trophic factor withdrawal or β-amyloid. Transfection of antisense PS2 conferred protection against apoptosis induced by trophic withdrawal in nerve growth factor-differentiated or amyloid precursor protein-expressing PC12 cells. The apoptotic cell death induced by PS2 protein was sensitive to pertussis toxin, suggesting that heterotrimeric GTP-binding proteins are involved. A PS2 mutation associated with familial Alzheimer's disease was found to generate a molecule with enhanced basal apoptotic activity. This gain of function might accelerate the process of neurodegeneration that occurs in Alzheimer's disease, leading to the earlier age of onset characteristic of familial Alzheimer's disease.

Bibliography

Wolozin, B., Iwasaki, K., Vito, P., Ganjei, J. K., LacanÃ , E., Sunderland, T., Zhao, B., Kusiak, J. W., Wasco, W., & DâAdamio, L. (1996). Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation. Science, 274(5293), 1710â1713.

Authors 10

Benjamin Wolozin (first)
Katsunori Iwasaki (additional)
Pasquale Vito (additional)
J. Kelly Ganjei (additional)
Emanuela Lacanà (additional)
Trey Sunderland (additional)
Boyu Zhao (additional)
John W. Kusiak (additional)
Wilma Wasco (additional)
Luciano D'Adamio (additional)

References 28 Referenced 324

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:45 a.m.)
Deposited	1 year ago (Aug. 7, 2024, 7:45 a.m.)
Indexed	1 month ago (July 30, 2025, 9:59 a.m.)
Issued	28 years, 8 months ago (Dec. 6, 1996)
Published	28 years, 8 months ago (Dec. 6, 1996)
Published Print	28 years, 8 months ago (Dec. 6, 1996)

Funders 0

None

BibTeX

@article{Wolozin_1996, title={Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation}, volume={274}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.274.5293.1710}, DOI={10.1126/science.274.5293.1710}, number={5293}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Wolozin, Benjamin and Iwasaki, Katsunori and Vito, Pasquale and Ganjei, J. Kelly and Lacanà, Emanuela and Sunderland, Trey and Zhao, Boyu and Kusiak, John W. and Wasco, Wilma and D’Adamio, Luciano}, year={1996}, month=dec, pages={1710–1713} }

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