DOI: 10.1126/science.274.5288.798. Hyperresponsive B Cells in CD22-Deficient Mice

Hyperresponsive B Cells in CD22-Deficient Mice

10.1126/science.274.5288.798

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. Splenic B cells from mice with a disrupted CD22 gene were found to be hyperresponsive to receptor signaling: Heightened calcium fluxes and cell proliferation were obtained at lower ligand concentrations. The mice gave an augmented immune response, had an expanded peritoneal B-1 cell population, and contained increased serum titers of autoantibody. Thus, CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering.

Bibliography

OâKeefe, T. L., Williams, G. T., Davies, S. L., & Neuberger, M. S. (1996). Hyperresponsive B Cells in CD22-Deficient Mice. Science, 274(5288), 798â801.

Authors 4

Theresa L. O'Keefe (first)
Gareth T. Williams (additional)
Sarah L. Davies (additional)
Michael S. Neuberger (additional)

References 33 Referenced 442

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:37 a.m.)
Deposited	1 year ago (Aug. 7, 2024, 7:29 a.m.)
Indexed	1 week, 3 days ago (Aug. 21, 2025, 2:18 p.m.)
Issued	28 years, 9 months ago (Nov. 1, 1996)
Published	28 years, 9 months ago (Nov. 1, 1996)
Published Print	28 years, 9 months ago (Nov. 1, 1996)

Funders 0

None

BibTeX

@article{O_Keefe_1996, title={Hyperresponsive B Cells in CD22-Deficient Mice}, volume={274}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.274.5288.798}, DOI={10.1126/science.274.5288.798}, number={5288}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={O’Keefe, Theresa L. and Williams, Gareth T. and Davies, Sarah L. and Neuberger, Michael S.}, year={1996}, month=nov, pages={798–801} }

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